Chiasmal infarction and sudden blindness caused by mucormycosis in AIDS and diabetes mellitus

American Journal of Ophthalmology
B L LeeB J Glasgow

Abstract

To report rapidly progressive rhino-orbitocerebral mucormycosis in a 47-year-old woman with both diabetes mellitus and the acquired immunodeficiency syndrome (AIDS). Case report including postmortem examination of the eyes, orbit, and brain of a patient with rhino-orbitocerebral mucormycosis, diabetes mellitus, and AIDS. Invasion by hyphae of the Rhizopus species produced an occlusive vasculitis and massive infarction of the optic chiasm. Fungal organisms were discovered in multiple granulomata of the optic nerve. Infarction at the optic chiasm probably caused sudden blindness in this patient.

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Oct 2, 2001·Survey of Ophthalmology·M DinowitzL Frohman
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