Chicken cerebrospinal fluid: normal composition and response to insulin administration

The Journal of Physiology
D K Anderson, R L Hazelwood

Abstract

1. With the exception of Na, K and Cl clear cerebrospinal fluid (c.s.f.) obtained from chickens varying in age from 6 weeks to 2 years did not reveal significant alterations in composition as could be related to age per se.2. Considerably higher levels of total protein and glucose are found in chicken c.s.f. than are found in mammalian fluid; slightly more chloride is found in chicken than most mammalian c.s.f.'s.3. Intravenous beef insulin depressed chicken cerebrospinal fluid glucose levels; insulin placed intracisternally had no effect on the avian glycogen body glycogen content indicating that c.s.f. glucose constancy, with or without glycogen body assistance, is not responsible for the resistance of the chicken to pharmacological doses of insulin.4. Bovine insulin injected into the cisterna magna of chickens depresses plasma glucose partially by acting over vagal pathways to release endogenous insulin and partially by diffusion across the c.s.f.-blood barrier to exert a peripheral effect.

Citations

Mar 1, 1981·Diabetologia·D Porte, S C Woods
Aug 1, 1975·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·D K AndersonS R Heisey
May 1, 1978·Physiology & Behavior·M E GibbsK T Ng
Apr 15, 1975·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A S FinkR R Howell
Jan 1, 1970·Journal of Neurobiology·A Van Harreveld, E Fifkova
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·C R Plata-Salamán
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yufei YuRenato Rozental
May 19, 2018·The Journal of Physiology·Norman R SaundersMark D Habgood
Nov 1, 1971·Journal of Neurochemistry·A Van Harreveld, E Fifkova
Jan 1, 1972·Journal of Neurochemistry·A Van Harreveld, E Fifkova
Mar 1, 1981·Diabetologia·D Porte, S C Woods
Feb 1, 1976·Zeitschrift für Tierpsychologie·J D DeliusC Chaudoir
Feb 1, 1981·The American Journal of Physiology·A IguchiA J Szabo

Related Concepts

Metazoa
Blood - Brain Barrier Anatomy
Bos indicus
Cerebrospinal Fluid
Cerebrospinal Fluid Proteins
Chloride Ion Level
Diffusion
Canis familiaris
Anhydrous Dextrose
Glycogen

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