Chicken collagen hydrolysate reduces proinflammatory cytokine production in C57BL/6.KOR-ApoEshl mice

Journal of Nutritional Science and Vitaminology
Youzuo ZhangFumiki Morimatsu

Abstract

Effects of chicken collagen hydrolysate (CCH) on atherogenesis in apolipoprotein E-deficient C57BL/6.KOR-ApoE(shl) mice were investigated in this paper. The mice were fed on either a normal CE-2 diet (control group) or a diet containing 10% CCH (CCH group) for 12 wk. Compared with that of the control, the amount of total plasma cholesterol, total hepatic cholesterol and hepatic triglycerides in the CCH group was reduced by 14.4, 24.7 and 42.8%, respectively. Histological analysis results showed that the abundance of diffuse hepatic lipid droplets and fat vacuoles was decreased in the CCH group. Meanwhile, the concentration of proinflammatory cytokines in the CCH group plasma, including interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1), and tumor necrosis factor-alpha (TNF-alpha), was downregulated by 43.4, 17.9 and 24.1%, respectively. The present results suggested that CCH treatment might help prevent atherosclerosis through not only its lipid-lowering effects but also inhibiting expression of inflammatory cytokines.

References

Sep 23, 2000·Nature·A J Lusis
Mar 10, 2001·Cell·C K Glass, J L Witztum
Feb 28, 2002·Journal of Atherosclerosis and Thrombosis·Y MatsushimaM Tachibana
Dec 20, 2002·Nature·Peter Libby
Sep 24, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Olivera MarkovicRobert F Grimble
Jun 3, 2006·Stroke; a Journal of Cerebral Circulation·Guido Stoll, Martin Bendszus
Sep 24, 2008·Journal of Agricultural and Food Chemistry·Ai SaigaFumiki Morimatsu
Oct 8, 2008·Bioscience, Biotechnology, and Biochemistry·Kenji MatsumotoNobuki Gato
Feb 23, 2010·Journal of Medicinal Food·Youzuo ZhangFumiki Morimatsu

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Citations

Feb 15, 2014·BioMed Research International·Subhadeep ChakrabartiJianping Wu
Nov 29, 2011·Molecular Nutrition & Food Research·Anthony Cam, Elvira Gonzalez de Mejia
May 16, 2015·Critical Reviews in Food Science and Nutrition·Audrey DaneaultYohann Wittrant
Jan 25, 2017·International Journal of Molecular Sciences·Saskia SchadowJuergen Steinmeyer
Mar 10, 2017·International Journal of Biological Macromolecules·Palaniappan SeedeviAnnaian Shanmugam
Oct 31, 2012·Food & Function·Ashton Howard, Chibuike C Udenigwe
Feb 3, 2018·Critical Reviews in Food Science and Nutrition·Yu FuRené Lametsch
Jun 22, 2013·Experimental Biology and Medicine·Anita HartogJohan Garssen

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