Chicken IgY facilitates allergic airway inflammation in a chemical-induced murine asthma model by potentiating IL-4 release

Toxicology Letters
Lihong YaoShaoxi Cai

Abstract

High mobility group box 1 (HMGB1) is a DNA-binding protein that is abundantly expressed in most tissues. Recently, HMGB1 has gained much attention for its regulation of immunity and inflammation. Yet its role in toluene diisocyanate (TDI)-induced asthma still remains poorly characterized. In this study, mice were sensitized and challenged with TDI to establish a TDI-induced asthma model. An IgY anti-HMGB1 antibody or isotype IgY was given intraperitoneally after each challenge. Airway reactivity to methacholine, airway inflammation, bronchial epithelial hyperplasia and shedding were unexpectedly aggravated after administration of the anti-HMGB1 antibody and was accompanied by increased pulmonary expression of HMGB1, especially in those mice treated with IgY. Levels of IL-4, IL-5, IL-13 and TNF-α were also elevated with TDI-induction. Primary lymphocytes from TDI sensitized and challenged mice demonstrated increased secretion of IL-4 after IgY stimulation. To confirm the effect of IgY, a cohort of mice exposed to TDI or vehicle was injected with IgY and the same results were observed after IgY treatment as in TDI asthmatic mice. Taken together, these results show that the IgY anti-HMGB1 antibody can facilitate TDI-induced allerg...Continue Reading

References

Jul 1, 1976·British Journal of Pharmacology·N Chand, P Eyre
Jan 1, 1980·International Archives of Allergy and Applied Immunology·M E RoseJ W Bradley
Aug 1, 1995·Immunology Today·G W WarrD A Higgins
Mar 1, 1995·American Journal of Respiratory Cell and Molecular Biology·G BrusselleR Pauwels
Oct 1, 1993·Poultry Science·A LarssonP O Forsberg
Mar 16, 2000·Developmental and Comparative Immunology·M A QureshiI Hussain
Aug 22, 2000·The Journal of Experimental Medicine·U AnderssonK J Tracey
Sep 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Luis UlloaKevin J Tracey
Sep 5, 2002·Nature Reviews. Immunology·Martin F Flajnik
Oct 3, 2002·American Journal of Respiratory Cell and Molecular Biology·Joanna M MathesonMichael I Luster
Dec 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Huan YangKevin J Tracey
Jan 11, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jae Yeol KimEdward Abraham
Mar 9, 2005·The Journal of Allergy and Clinical Immunology·Stephen HolgateColin Reisner
Mar 30, 2005·The Journal of Experimental Medicine·Allan TsungTimothy R Billiar
Aug 8, 2006·The Journal of Allergy and Clinical Immunology·Charles PerkinsFred D Finkelman
Jun 30, 2007·Biochemical and Biophysical Research Communications·Shin MaedaMasao Omata
Apr 11, 2008·The Journal of Biological Chemistry·Alexander I TaylorRosaleen A Calvert
Apr 29, 2008·American Journal of Respiratory Cell and Molecular Biology·Naoki HamadaYoichi Nakanishi
Jun 25, 2008·Circulation·Martin AndrassyAngelika Bierhaus
Dec 23, 2008·American Journal of Respiratory Cell and Molecular Biology·Rina TakamiyaMark A Perrella
Dec 2, 2009·Biochimica Et Biophysica Acta·Huan Yang, Kevin J Tracey
Mar 3, 2010·Annual Review of Immunology·Gary P SimsAnthony J Coyle
Jun 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Huan YangKevin J Tracey
Jan 12, 2011·Annual Review of Immunology·Ulf Andersson, Kevin J Tracey
Feb 2, 2012·Nature Reviews. Rheumatology·Helena Erlandsson HarrisDavid S Pisetsky
May 9, 2012·Nature Medicine·Stephen J Galli, Mindy Tsai
Aug 23, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E-J ShimH-W Park
Nov 17, 2012·Poultry Science·A PolanowskiT Trziszka
Jan 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ben LuKevin J Tracey
Feb 14, 2014·The New England Journal of Medicine·Susan M Tarlo, Catherine Lemiere

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Citations

May 10, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shuyu ChenAilin Tao
Jun 21, 2017·Clinical and Molecular Allergy : CMA·Egidio ImbalzanoSebastiano Gangemi
Jun 29, 2021·Frontiers in Immunology·Lucia LeeDaria Mochly-Rosen

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