PMID: 7536924Apr 11, 1995Paper

Chicken interferon consensus sequence-binding protein (ICSBP) and interferon regulatory factor (IRF) 1 genes reveal evolutionary conservation in the IRF gene family

Proceedings of the National Academy of Sciences of the United States of America
C JungwirthI B Dawid

Abstract

Members of the IRF family mediate transcriptional responses to interferons (IFNs) and to virus infection. So far, proteins of this family have been studied only among mammalian species. Here we report the isolation of cDNA clones encoding two members of this family from chicken, interferon consensus sequence-binding protein (ICSBP) and IRF-1. The predicted chicken ICSBP and IRF-1 proteins show high levels of sequence similarity to their corresponding human and mouse counterparts. Sequence identities in the putative DNA-binding domains of chicken and human ICSBP and IRF-1 were 97% and 89%, respectively, whereas the C-terminal regions showed identities of 64% and 51%; sequence relationships with mouse ICSBP and IRF-1 are very similar. Chicken ICSBP was found to be expressed in several embryonic tissues, and both chicken IRF-1 and ICSBP were strongly induced in chicken fibroblasts by IFN treatment, supporting the involvement of these factors in IFN-regulated gene expression. The presence of proteins homologous to mammalian IRF family members, together with earlier observations on the occurrence of functionally homologous IFN-responsive elements in chicken and mammalian genes, highlights the conservation of transcriptional mechanis...Continue Reading

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Citations

Jun 1, 1996·Cytokine & Growth Factor Reviews·A R BluyssenD E Levy
Apr 6, 2004·Developmental and Comparative Immunology·Pete KaiserSucharitha Balu
Jan 25, 2003·Developmental and Comparative Immunology·Bertrand ColletChristopher J Secombes
Aug 24, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·B ZöllerC Jungwirth
Jan 19, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·P StaeheliB Kaspers
Dec 19, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M BehrC Jungwirth
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tomohiko Tamura, Keiko Ozato
Apr 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·R MarienfeldC Jungwirth
Dec 25, 2002·Annual Review of Psychology·Barbara RogoffCathy Angelillo
Sep 5, 2001·Molecular and Cellular Biology·R HrdlickováH R Bose
Jun 12, 2013·Developmental and Comparative Immunology·Kate E GoossensAndrew G D Bean
Aug 22, 2006·Developmental and Comparative Immunology·Jianguo XiaKatharine E Magor
Oct 1, 1996·European Journal of Immunology·K C WeiningP Staeheli
Apr 26, 1996·The Journal of Biological Chemistry·M SchwemmleU Schultz

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