Chicken intrapulmonary chemoreceptors: discharge at static levels of intrapulmonary carbon dioxide and their location

Respiration Physiology
P C Nye, R E Burger

Abstract

We studied 54 intrapulmonary chemoreceptors in the unidirectionally ventilated left lungs of 12 thoracotomized cockerels. We ligated the left pulmonary artery to eliminate CO2 contributed by mixed venous blood. At zero PCO2 many units discharge irregularly, and some cease discharging after several seconds. Discharge frequencies at 13.7 torr PCO2 and above are described by logarithmic regressions. The slopes and intercepts of the logarithmic regressions are correlated so that the average response can be written: frequency = 3.86 -B . 1n (24.5 PCO2-1). Afferent activity above 6.8 torr PCO2 is described by 0.073 + 78.6 exp (-0.11 PCO2) -63.3 exp (-0.15 PCO2). For each unit, receptive site PCO2 in a perfused lung was assumed to be the PCO2 in the unperfused lung which gave the same discharge frequency. Location of the receptor was determined as the fraction of ventilation-perfusion region which had the same PCO2 as receptive site PCO2. Two major concentrations of receptors accounted for 85% of the total, one near the entering gas and one near the middle of the gas-exchange region. Sensitivity of individual receptors did not vary systematically with location.

References

Feb 1, 1977·Respiration Physiology·R B Banzett, R E Burger
Aug 1, 1977·Respiration Physiology·J L OsborneF L Powell
Oct 1, 1974·Respiration Physiology·M R FeddeP Scheid
Sep 1, 1973·IEEE Transactions on Bio-medical Engineering·R E BurgerW Wallace
Sep 1, 1970·Poultry Science·J D Henry, M R Fedde
Aug 1, 1970·The Journal of Physiology·M R Fedde, D F Peterson

Citations

Mar 1, 1978·Respiration Physiology·R E Burger, J A Estavillo
Feb 1, 1980·Respiration Physiology·J K BoonM R Fedde
Sep 1, 1980·Respiration Physiology·F L PowellR E Burger
Nov 1, 1983·Respiration Physiology·G M BarnasR E Burger
Sep 1, 1983·Respiration Physiology·J P Kiley, M R Fedde
Sep 1, 1984·Respiration Physiology·S C Hempleman, R E Burger
Dec 1, 1985·Respiration Physiology·D L KilgoreM R Fedde
Aug 1, 1985·Respiration Physiology·S C Hempleman, R E Burger
Oct 1, 1986·Respiration Physiology·S C HemplemanR E Burger
Sep 1, 1990·Respiration Physiology·J A EstavilloR E Burger
Nov 1, 1993·Respiration Physiology·T P Adamson, Irene C Solomon
Nov 1, 1994·Respiration Physiology·T P AdamsonIrene C Solomon
Jan 1, 1982·Comparative Biochemistry and Physiology. A, Comparative Physiology·J K BoonP Scheid
Jan 1, 1985·Comparative Biochemistry and Physiology. A, Comparative Physiology·J O HamboluM R Fedde
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·R F Burton
Jun 14, 2005·Respiratory Physiology & Neurobiology·Jason Q Pilarski, S C Hempleman
Jan 29, 2002·Respiration Physiology·J M Shoemaker, S C Hempleman
Nov 1, 1996·Respiration Physiology·R D TallmanM C Khoo
Jan 1, 1979·Computers in Biology and Medicine·S C HemplemanR E Burger
Dec 1, 1990·Respiration Physiology·J PizarroG S Mitchell
Feb 10, 1999·The American Journal of Physiology·D E Bebout, S C Hempleman
Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S C HemplemanRowin S Begay
Feb 22, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S C HemplemanIrene C Solomon

Related Concepts

Nerve Impulses
Afferent Pathways
Metazoa
Carbon Dioxide
Chemoreceptor Cells
Pulmonary Artery Structure
Vagus Nerve Structure
Ventilation-Perfusion Ratio

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