PMID: 8460128Mar 15, 1993Paper

Chicken neuronal acetylcholine receptor alpha 2-subunit gene exhibits neuron-specific expression in the brain and spinal cord of transgenic mice

Proceedings of the National Academy of Sciences of the United States of America
P DaubasJ P Changeux

Abstract

Transgenic mice carrying the complete structural gene of the alpha 2 subunit of the chicken neuronal nicotinic acetylcholine receptor (nAChR) and 7 kilobase pairs (kbp) of 5' upstream and 3 kbp of 3' downstream sequences have been generated. The transgene was stably integrated in transgenic lines and transmitted to their progeny. Avian transgene expression was predominant in the central nervous system as detected by specific alpha 2-subunit cDNA amplification. Moreover, in at least two independent mouse lines, its expression appeared to be neuron-specific and reproducibly restricted to subregions in the brain and spinal cord, as revealed by in situ hybridization histochemistry. Most cranial motor nuclei were positive, and several of the alpha 2-subunit transgene-expressing structures corresponded to cholinergic areas in rodents. This study reveals that regulatory mechanisms giving rise to neuronal-specific gene expression have been conserved at least in part between birds and mammals.

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Citations

Apr 12, 2002·Progress in Neurobiology·A Merighi
Nov 19, 1997·Progress in Neurobiology·C GottiF Clementi
Jun 28, 2011·Biochemical Pharmacology·Anne TammimäkiJerry A Stitzel
Jan 1, 1997·Journal of Receptor and Signal Transduction Research·R S BroideH Soreq
Nov 5, 1997·The Journal of Biological Chemistry·C B BiggerP D Gardner
Nov 1, 1995·Journal of Neurogenetics·R M Twyman, E A Jones

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