PMID: 8603050Jan 1, 1996Paper

Chicken ovalbumin upstream promoter-transcription factors and their regulation

The Journal of Steroid Biochemistry and Molecular Biology
Y QiuM J Tsai

Abstract

COUP-TFs are orphan members of the steroid/thyroid hormone receptor superfamily. COUP-TF homologues have been cloned in several species, from Drosophila to man. The vertebrate COUP-TFs can be classified into four subgroups according to sequence homology in their ligand-binding domain. COUP-TFs bind to AGGTCA direct repeats or palindromes with various spacings. These include the response elements of several other members of the superfamily, the vitamin D receptor, the thyroid hormone receptor, the retinoic acid receptor, the retinoid X receptor, the peroxisome proliferation activated regulator, and the hepatocyte nuclear factor-4. COUP-TF response elements have been identified in the promoters of many genes and COUP-TFs have been shown to act as negative regulators both in vitro and in vivo. They can compete with the above mentioned receptors for binding to the common response elements. The ratio of COUP-TF and the other positive regulator determines the transcriptional state of the particular gene in any given moment. COUP-TFs are expressed in the developing central nervous system of mouse and zebra-fish. In addition, they are also expressed in many organs during mouse organogenesis. The expression pattern and profile of COUP-T...Continue Reading

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Citations

Apr 18, 2008·The Cerebellum·Yei-Tsung ChenChawnshang Chang
Jun 5, 2002·Journal of Hepatology·Saul J Karpen
May 9, 2002·Molecular and Cellular Endocrinology·S ZhouV K Walker
Oct 29, 2003·Experimental Gerontology·Abdelnaby KhalyfaEugenia Wang
Aug 29, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Tomoshige KinoGeorge P Chrousos
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Jun 13, 2014·Cell Communication and Signaling : CCS·Natascha Hermann-Kleiter, Gottfried Baier
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Jun 26, 2015·International Journal of Molecular Sciences·Rui ZhangGuoxun Chen
Sep 13, 2014·Journal of Cellular Physiology·In-Hong KangJeong-Tae Koh
Jul 15, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Xiaoyong ZhiH Eric Xu
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