Chicks injected with antisera to either S-100 alpha or S-100 beta protein develop amnesia for a passive avoidance task

Neurobiology of Learning and Memory
B S O'DowdS R Robinson

Abstract

The cellular expression of S-100 beta protein is upregulated in Alzheimer's disease and in Down's syndrome, and this protein has been implicated in memory-related processes in laboratory animals. However, the possibility that the alpha subunit of S-100 is also involved in memory has not yet been examined. In the present study, day-old black Australorp white Leghorn cockerel chicks (Gallus domesticus) received injections of monoclonal antisera to S-100 alpha (1:50) or S-100 beta (1:500) into each hemisphere immediately after training on a one-trial passive avoidance task. The chicks displayed significantly lower retention levels than control birds that had been injected with antisera to carbonic anhydrase, or with saline (p < .01). S-100 alpha antisera had an amnestic effect when injected between 0 and 20 min after training, with memory deficits occurring from 30 min post-learning, at the point of transition between the A and the B phases of the Gibbs-Ng intermediate memory stage. By contrast, the S-100 beta antisera needed to be injected either 5 min before or immediately after training and produced amnesia 10 min earlier, at the start of the A phase of the intermediate memory stage. We conclude that the two subunits of the S-1...Continue Reading

References

Oct 1, 1979·Neuroscience Letters·M E GibbsK T Ng
Jan 1, 1992·Canadian Journal of Physiology and Pharmacology·R A Swanson
Nov 10, 1992·Biochimica Et Biophysica Acta·S W BargerL J Van Eldik
Jan 1, 1992·Neuroscience and Behavioral Physiology·L A GromovG V Ovinova
May 1, 1991·Trends in Neurosciences·M GoedertC C Garner
Jan 1, 1991·Molecular Neurobiology·K H PfenningerS Quiroga
Jan 1, 1990·Advances in Experimental Medicine and Biology·M S FazeliT V Bliss
Jan 1, 1990·Journal of Molecular Neuroscience : MN·K KatoT Yamanaka
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W S GriffinC Araoz
Sep 24, 1986·Brain Research·D Lewis, T J Teyler
Dec 1, 1986·The Journal of Cell Biology·D G Drubin, M W Kirschner
Dec 15, 1987·Brain Research·L J Van Eldik, D B Zimmer
Mar 1, 1987·The American Journal of Physiology·D B Zimmer, L J Van Eldik
Oct 11, 1974·Nature·K HaglidL Ronnback
Dec 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·H Hydén, P W Lange
Sep 1, 1981·Cellular and Molecular Neurobiology·H Hydén, P W Lange
Jun 1, 1984·Journal of Neurochemistry·V E ShashouaB W Moore
Mar 1, 1980·Journal of the Neurological Sciences·H HydénS Larsson
May 1, 1995·Trends in Neurosciences·J DeZazzo, T Tully
Jan 1, 1995·Brain Research Bulletin·D B ZimmerW Song
Jan 23, 1995·Behavioural Brain Research·P PasinelliW H Gispen
Sep 1, 1994·Brain Research. Molecular Brain Research·L H LinJ J Norden
Feb 28, 1994·Behavioural Brain Research·W Q ZhaoK T Ng
Mar 18, 1994·Brain Research. Developmental Brain Research·B S O'DowdL Hertz
Apr 1, 1993·Cell Calcium·D B Zimmer, J G Dubuisson
Jul 1, 1995·Neurobiology of Aging·M D LedesmaI Correas
Apr 18, 1996·Nature·J HeierhorstB E Kemp
Mar 1, 1996·Journal of Neuropathology and Experimental Neurology·R E MrakW S Griffin

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Citations

Dec 19, 2006·Evidence-based Complementary and Alternative Medicine : ECAM·O I EpsteinM B Shtark
Dec 17, 2004·BMC Neurology·Henrik JönssonSten Blomquist
Sep 21, 2007·Clinical and Experimental Pharmacology & Physiology·Evelin VicenteCarlos A Gonçalves
Feb 21, 2008·The Journal of Pharmacy and Pharmacology·Vincent CastagneOleg I Epstein
Aug 15, 2013·Journal of Neural Transmission·Zhao-Liang Sun, Dong-Fu Feng
Oct 11, 2019·Journal of Neurotrauma·Justus BaeckerAndrea Kleindienst
Mar 20, 2003·Microscopy Research and Technique·Matthias RothermundtVolker Arolt
Jun 4, 2019·Frontiers in Neuroscience·Joana S Cristóvão, Cláudio M Gomes
Dec 26, 2001·Brain Research Bulletin·P M Whitaker-Azmitia
Oct 20, 1999·Journal of Cardiothoracic and Vascular Anesthesia·D A StumpK D Rorie
Oct 19, 2006·Biochimica Et Biophysica Acta·Gabriele E AckermannClaus W Heizmann
May 20, 2009·Journal of Molecular Biology·Nathan T WrightDavid J Weber

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