Chief cell-predominant gastric polyps: a series of 12 cases with literature review

Histopathology
Karen ChanM Priyanthi Kumarasinghe

Abstract

Rare gastric lesions composed of a combined proliferation of chief and oxyntic cells have been variably called adenocarcinoma of fundic gland type and oxyntic gland polyp/adenoma. Herein, we present a series of cases that show a morphological spectrum of chief and oxyntic cell proliferations. Routine and consultation cases were collated from five institutions. Information regarding site, size, endoscopic appearance, clinical history and medication use, when available, was accrued, as was the histological features and immunoprofiles. A total of 12 cases were collated. Age ranged from 39 to 81 years. All the lesions were located in the fundus; seven of eight were polypoid lesions endoscopically. Lesions were primarily solitary, averaged 4.6 mm in diameter (largest 9 mm) and comprised >50% chief cells. The predominant architectural pattern was of anastomosing and solid and clustered glands or a mixture of these patterns. Lesions were limited mainly to the mucosa, although two showed submucosal involvement. None had known metastatic disease. This series included lesions that were previously described as gastric adenocarcinoma of fundic gland type and oxyntic gland polyp/adenoma. They are located exclusively in the fundus and compos...Continue Reading

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Citations

Jun 28, 2017·Virchows Archiv : an International Journal of Pathology·Hussein NassereddineAnne Couvelard
Apr 13, 2018·American Journal of Clinical Pathology·Mark A BenedictDhanpat Jain
Aug 4, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Tetsuo UshikuMasashi Fukayama
Aug 2, 2019·World Journal of Clinical Cases·Ya-Nan YuZi-Bin Tian
Jan 21, 2021·Microorganisms·Simone BertzMichael Vieth

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