Chikungunya Virus: An Emergent Arbovirus to the South American Continent and a Continuous Threat to the World

Frontiers in Microbiology
Marcela S CunhaLuciana J da Costa

Abstract

Chikungunya virus (CHIKV) is an arthropod-borne virus (arbovirus) of epidemic concern, transmitted by Aedes ssp. mosquitoes, and is the etiologic agent of a febrile and incapacitating arthritogenic illness responsible for millions of human cases worldwide. After major outbreaks starting in 2004, CHIKV spread to subtropical areas and western hemisphere coming from sub-Saharan Africa, South East Asia, and the Indian subcontinent. Even though CHIKV disease is self-limiting and non-lethal, more than 30% of the infected individuals will develop chronic disease with persistent severe joint pain, tenosynovitis, and incapacitating polyarthralgia that can last for months to years, negatively impacting an individual's quality of life and socioeconomic productivity. The lack of specific drugs or licensed vaccines to treat or prevent CHIKV disease associated with the global presence of the mosquito vector in tropical and temperate areas, representing a possibility for CHIKV to continually spread to different territories, make this virus an agent of public health burden. In South America, where Dengue virus is endemic and Zika virus was recently introduced, the impact of the expansion of CHIKV infections, and co-infection with other arbovir...Continue Reading

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Citations

Mar 27, 2021·Current Opinion in Neurology·Arun Venkatesan
Jun 25, 2021·Frontiers in Microbiology·Nadim SharifShuvra Kanti Dey
Jul 3, 2021·Tropical Medicine and Infectious Disease·Elizabeth M TraverseKelli L Barr

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Methods Mentioned

BETA
glycosylation
protein folding
nuclear translocation

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