Oct 26, 2010

Child health, developmental plasticity, and epigenetic programming

Endocrine Reviews
Ze'ev HochbergK Albertsson-Wikland

Abstract

Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to the organism under changing environments. Environmental conditions that are experienced in early life can profoundly influence human biology and long-term health. Developmental origins of health and disease and life-history transitions are purported to use placental, nutritional, and endocrine cues for setting long-term biological, mental, and behavioral strategies in response to local ecological and/or social conditions. The window of developmental plasticity extends from preconception to early childhood and involves epigenetic responses to environmental changes, which exert their effects during life-history phase transitions. These epigenetic responses influence development, cell- and tissue-specific gene expression, and sexual dimorphism, and, in exceptional cases, could be transmitted transgenerationally. Translational epigenetic research in child health is a reiterative process that ranges from research in the basic sciences, preclinical research, and pediatric clinical research. Identifying the epigenetic consequences of fetal programming creates potential applications in clinical practice: the ...Continue Reading

  • References518
  • Citations196

Mentioned in this Paper

Adult Disease
Exertion
Tissue-Specific Gene Expression
Placenta
Senility
Sexual Dimorphism
Fetal Programming
Study of Epigenetics
Endocrine System
Infant Development

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