Child-Pugh classification dependent alterations in serum leptin levels among cirrhotic patients: a case controlled study

BMC Gastroenterology
Fusun F BolukbasOya Ovunc

Abstract

As anorexia and hypermetabolism are common in cirrhosis, leptin levels may be increased in this disease. In this study, we investigated the relation between the severity of disease and serum leptin levels in post-hepatitis cirrhosis and the role of body composition, gender and viral aetiology of cirrhosis in this association. Thirty-five cases with post-hepatitis cirrhosis and 15 healthy controls were enrolled in this study. Body composition including body mass index, body fat percentage and body fat mass were determined. Serum leptin levels were assayed. Leptin levels were significantly higher among cirrhotic patients independent of sex compared to controls (p = 0.001). Female patients in both groups have had higher leptin levels than males (in cirrhotics p = 0.029, in controls p = 0.02). Cirrhotic patients in each of A, B and C subgroups according to the Child- Pugh classification revealed significantly different levels compared to controls (p = 0.046, p = 0.004, p = 0.0001, respectively). Male cirrhotics in Child-Pugh Class B and C subgroups had significantly higher leptin levels compared to male controls (p = 0.006, p = 0.008). On the other hand, female patients only in Child Pugh class C subgroup have had higher levels of ...Continue Reading

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Citations

Sep 8, 2006·Digestive Diseases and Sciences·Sotirios K Bethanis, Stamatios E Theocharis
Jun 2, 2007·BMC Gastroenterology·Spilios ManolakopoulosStamatios Theocharis
Jul 8, 2008·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Cristiana Bertolani, Fabio Marra
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