PMID: 18714796Aug 22, 2008Paper

Childhood absence epilepsy requiring more than one medication for seizure control

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
B Nadler, Michael I Shevell

Abstract

Absence epilepsy is the most common primary generalized epilepsy syndrome encountered in pediatric practice. Treatment is pharmacologically specific and usually successful with a single medication. The objective of this study was to identify any clinical or electroencephalographic features at initial presentation in a consecutive cohort of children with absence epilepsy that may be associated with the need for a second medication. A computerized pediatric neurology database (1991-2007 inclusive) was retrospectively searched for all patients with typical absence seizures, 3 Hz spike and wave on EEG and no apparent symptomatic etiology who were over the age of two years at seizure onset with at least one year of follow-up. All such children were then divided into two groups; a) those requiring a single medication for seizure control (Group 1), and b) those requiring two medications for seizure control despite optimal management with the initial medication as determined by serum drug monitoring (Group 2). Clinical and electrographic features evident at diagnosis were then contrasted between Group 1 and 2. Seventy-five children with absence seizures were initially identified with 52 meeting the study's inclusion and none of the exc...Continue Reading

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