Childhood abuse and depression in adulthood: The mediating role of allostatic load

Psychoneuroendocrinology
Sandra ScheuerFrank H Wilhelm

Abstract

Traumatic experiences during childhood are considered a major risk factor for depression in adulthood. Childhood trauma may induce physiological dysregulation with long-term effects of increased allostatic load until adulthood, which may lead to depression. Thus, our aim was to investigate whether allostatic load - which represents a multi-system measure of physiological dysregulation - mediates the association between childhood trauma and adult depression. The study sample consisted of 324 depressed inpatients participating in the Munich Antidepressant Response Signature (MARS) project and 261 mentally healthy control participants. The mediation analysis using a case-control approach included childhood trauma, i.e., physical and sexual abuse, as predictor variables and an allostatic load index comprised of 12 stress-related biomarkers as mediator. Age and sex were included as covariates. Mediation analyses revealed that the influence of physical abuse, but not sexual abuse, during childhood on depression in adulthood was mediated by allostatic load. This effect was moderated by age: particularly young (18-42 years) and middle-aged (43-54 years) adults with a history of physical abuse during childhood exhibited high allostatic ...Continue Reading

Citations

Nov 4, 2020·Biological Research for Nursing·Asha MathewUlf G Bronas
Jul 3, 2019·Schizophrenia Research·Patryk PiotrowskiBłażej Misiak
Jan 26, 2021·Psychoneuroendocrinology·Jay O'Shields, Jeremy J Gibbs
Feb 9, 2021·Frontiers in Psychiatry·Zhuoying WuHongjun Peng
Feb 21, 2021·Journal of Psychosomatic Research·Kirsi HonkalampiSoili M Lehto
Apr 27, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Błażej MisiakJerzy Samochowiec
Aug 14, 2021·Reviews in the Neurosciences·Jessica Daniela SchroderZuleide Maria Ignácio
Aug 18, 2020·Psychotherapy and Psychosomatics·Jenny GuidiGiovanni A Fava

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