Childhood and adolescent anxiety and depression: beyond heritability

Journal of the American Academy of Child and Adolescent Psychiatry
Sanja FranićDorret I Boomsma

Abstract

To review the methodology of behavior genetics studies addressing research questions that go beyond simple heritability estimation and illustrate these using representative research on childhood and adolescent anxiety and depression. The classic twin design and its extensions may be used to examine age and gender differences in the genetic determinants of complex traits and disorders, the role of genetic factors in explaining comorbidity, the interaction of genes and the environment, and the effect of social interaction among family members. An overview of the methods typically employed to address such questions is illustrated by a review of 34 recent studies on childhood anxiety and depression. The review provides relatively consistent evidence for small to negligible sex differences in the genetic etiology of childhood anxiety and depression, a substantial role of genetic factors in accounting for the temporal stability of these disorders, a partly genetic basis of the comorbidity between anxiety and depression, a possible role of the interaction between genotype and the environment in affecting liability to these disorders, a role of genotype-environment correlation, and a minor, if any, etiological role of sibling interacti...Continue Reading

References

Mar 1, 1992·Psychological Bulletin·E U Brady, P C Kendall
Jan 1, 1987·Journal of Psychiatric Research·L J Eaves
May 1, 1986·Behavior Genetics·G Carey
Mar 1, 1986·The American Journal of Psychiatry·K S Kendler, L J Eaves
Sep 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·R M RapeeL Evans
Aug 1, 1996·Journal of Abnormal Psychology·E J van den OordD I Boomsma
Dec 17, 1997·Nature Genetics·N MartinG Machin
Sep 29, 2000·The American Journal of Psychiatry·P F SullivanK S Kendler
Aug 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·J SilbergL Eaves
Oct 2, 2001·The American Journal of Psychiatry·J M HettemaK S Kendler
Feb 19, 2002·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Frances RiceAnita Thapar
May 28, 2002·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Minna HapponenRichard J Rose
Nov 29, 2002·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Frances RiceAnita Thapar
Feb 8, 2003·Twin Research : the Official Journal of the International Society for Twin Studies·Shaun Purcell
Oct 9, 2003·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Thalia C EleyRobert Plomin
Apr 2, 2004·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Renee D GoodwinL John Horwood
Apr 13, 2004·Journal of the American Academy of Child and Adolescent Psychiatry·Thalia C EleyShaun Purcell
Sep 8, 2005·Psychopathology·Thomas A Widiger
Dec 21, 2006·Psychological Medicine·Kenneth S Kendler, Jessica H Baker
Jun 15, 2007·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Sarah E BergenKenneth S Kendler
Aug 9, 2007·Emotion·Jeffrey A Ciesla, John E Roberts
Oct 13, 2007·Development and Psychopathology·Jennifer Y F LauThalia C Eley
Jan 24, 2008·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jennifer Y F Lau, Thalia C Eley
Feb 26, 2008·Psychological Medicine·K S KendlerP Lichtenstein
Apr 10, 2008·Nature Reviews. Genetics·Mark I McCarthyJoel N Hirschhorn
Aug 6, 2008·Archives of General Psychiatry·Marleen H M De MoorEco J C de Geus
Aug 14, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·Daniël S van GrootheestDorret I Boomsma
Nov 13, 2008·Developmental Psychology·Jurgita NarusytePaul Lichtenstein
Nov 26, 2008·Journal of Abnormal Psychology·Jennifer Y F Lau, Thalia C Eley
Jan 21, 2009·Annual Review of Clinical Psychology·Ronald M RapeeJennifer L Hudson
Feb 17, 2009·Thrombosis Research·Saskia Middeldorp
Jul 15, 2009·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Brian M HicksMatt McGue
Feb 11, 2010·European Child & Adolescent Psychiatry·Tobias BanaschewskiDavid Coghill
Apr 23, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·Diane J LambDorret I Boomsma
May 15, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Petra J G ZwijnenburgDorret I Boomsma
May 19, 2010·Nature Reviews. Genetics·Evan E EichlerJoseph H Nadeau

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Citations

Oct 16, 2012·Development and Psychopathology·Lauren M McGrathJordan W Smoller
Aug 4, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Inge L C van SoelenDorret I Boomsma
Apr 9, 2013·PloS One·Maciej TrzaskowskiRobert Plomin
Jan 14, 2012·Social Psychiatry and Psychiatric Epidemiology·Sylvana RobbersMeike Bartels
Dec 4, 2012·Journal of the American Academy of Child and Adolescent Psychiatry·Leslie RescorlaEugene Yuqing Zhang
Apr 28, 2012·Child and Adolescent Psychiatric Clinics of North America·John M WeirUma Rao
Jan 7, 2016·Frontiers in Behavioral Neuroscience·Liangwei Xia, Shuqiao Yao
Jul 19, 2012·Scandinavian Journal of Caring Sciences·Ratana SomrongthongOrapin Laosee
Jan 4, 2012·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Benjamin B Lahey, Irwin D Waldman
Jul 21, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·James J Hudziak, Stephen V Faraone
Aug 12, 2014·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jie ChenJianxin Zhang
Apr 23, 2015·Journal of Clinical Epidemiology·Ank P RingootPauline W Jansen
Apr 29, 2014·Journal of Affective Disorders·Gregory SwannBrian Mustanski
Apr 9, 2015·European Child & Adolescent Psychiatry·Sarah HohmannTobias Banaschewski
Feb 24, 2015·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Catherine Serra PoirierMichel Boivin
Mar 13, 2014·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Mara BrendgenMichel Boivin
Oct 16, 2016·Development and Psychopathology·Victoria C JohnsonElizabeth P Hayden
Oct 27, 2016·Journal of Child and Adolescent Psychopharmacology·Jawad H ButtEmil L Fosbøl
Oct 30, 2013·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Giovanni Abrahão SalumGisele Gus Manfro
Jul 6, 2017·Anxiety, Stress, and Coping·Núria VoltasJosefa Canals
May 4, 2016·Journal of Psychiatric Practice·Tabatha H MeltonShawn M McClintock
Aug 20, 2019·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Jessica P Lougheed
Nov 7, 2019·Psychology, Health & Medicine·Lauren B ShomakerJack A Yanovski
Jun 17, 2020·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Zeynep NasFrühling V Rijsdijk
Sep 7, 2017·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Anna J Markowitz
May 17, 2019·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Rebecca J BrookerH Hill Goldsmith
Jun 14, 2017·Journal of Abnormal Child Psychology·Mara Brendgen, François Poulin
Mar 7, 2020·BMC Psychiatry·Alejandra Caqueo-UrízarMatías Irarrázaval
Dec 7, 2013·Behavior Genetics·Jie ChenGordon T Harold
Feb 10, 2021·Psychological Medicine·Helga AskHeike Weber
Jan 8, 2021·Current Pain and Headache Reports·Maya Marzouk, Elizabeth K Seng

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