PMID: 12767452May 28, 2003Paper

Childhood and juvenile onset multiple sclerosis: clinical and paraclinical features

Brain & Development
Serkan OzakbaşBurak Yulug

Abstract

It is well known that multiple sclerosis (MS) is a demyelinating disease of the central nervous system that mostly starts in the second to third decade. In the present study, we reviewed our own observations of the clinical and paraclinical features in the 36 of 890 (4.04%) MS patients whose symptoms started before 16 years of age. The average age at onset of the disease in these 36 patients was 12.9 years. In 18 patients, the disease onset was monosymptomatic. Diplopia and sensory disturbances were the most common initial manifestations and occurred in 27.7% of cases. Twenty-one patients (59%) had a relapsing and 11 patients (30.5%) had a secondary progressive course. On the last evaluation, the EDSS score was above 5 in 11 patients and it was below 5 in 21 patients. As a result of this study, we concluded that childhood onset MS does not significantly differ from that it has been typically seen in adults in terms of major clinical manifestations and course of disease.

References

Sep 1, 1992·Acta Neurologica Scandinavica·E SindernU Wurster
Jan 1, 1988·Clinical Pediatrics·F J DiMario, P H Berman
Sep 1, 1987·The Journal of Pediatrics·P DuquetteW Hader
Aug 1, 1984·Archives of Neurology·J M Bejar, D K Ziegler
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Jan 1, 1996·European Neurology·D SelcenY Renda
Feb 1, 1997·Multiple Sclerosis : Clinical and Laboratory Research·A GhezziM Zaffaroni
Aug 17, 1999·Neurology·M RuggieriL M Grimaldi
Sep 1, 1999·Multiple Sclerosis : Clinical and Laboratory Research·A J Thompson

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Citations

Nov 1, 2012·Acta neurologica Belgica·Masoud EtemadifarPeyman Roomizadeh
Oct 15, 2009·Nature Reviews. Neurology·E Ann YehUNKNOWN US Network of Pediatric Multiple Sclerosis Centers of Excellence
Jun 22, 2007·The New England Journal of Medicine·Christel RenouxUNKNOWN Adult Neurology Departments KIDMUS Study Group
Feb 26, 2010·Annals of Indian Academy of Neurology·Yashma PatelLauren Krupp
Jul 3, 2007·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A GhezziUNKNOWN Immunomodulatory Treatment of Early-onset MS (ITEMS) Group
May 15, 2007·Current Opinion in Neurology·Til MengeOlaf Stüve
Sep 14, 2014·Journal of the Neurological Sciences·Elhachmia Ait Ben HaddouMohamed Yahyaoui
Apr 24, 2013·Neuroimaging Clinics of North America·Leonard H VerheyBrenda Banwell
Jun 7, 2008·Clinical Neurology and Neurosurgery·Christel RenouxChristian Confavreux
Dec 5, 2015·Indian Journal of Pediatrics·Sniya Valsa SudhakarManohar Shroff
Nov 1, 2006·Pediatric Neurology·Wen-Chin WengWang-Tso Lee
Jul 13, 2004·Pediatric Neurology·Atsushi MizotaEmiko Adachi-Usami
Jan 23, 2015·Annals of Neurology·Sabine PfeifenbringWolfgang Brück
Nov 12, 2013·Arquivos de neuro-psiquiatria·Yara Dadalti FragosoAlex Eduardo da Silva
Jun 9, 2005·Expert Review of Neurotherapeutics·Brenda Banwell
Mar 17, 2016·Journal of Child Neurology·Masoud EtemadifarMahboobeh Fereidan-Esfahani
Sep 26, 2020·Therapeutic Advances in Neurological Disorders·Raed AlroughaniAly Ezzat
Jul 15, 2015·European Journal of Pediatrics·Silvia Dell'AvventoStefano Sotgiu
Aug 21, 2021·International Medical Case Reports Journal·Nada Al-YousufMoiz Bakhiet
Jul 1, 2016·Pediatrics·Anita L BelmanUNKNOWN US Network of Pediatric MS Centers

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