Childhood and teenage physical activity and breast cancer risk

Breast Cancer Research and Treatment
Nicole M NiehoffDale P Sandler

Abstract

Adult physical activity is associated with reduced breast cancer risk, but few studies have evaluated activity before adulthood. Early life may be an important period because of rapid breast development and hormonal changes. This study contributes new information by examining childhood (ages 5-12) and teenage (ages 13-19) activity separately and overall. The Sister Study is a cohort of 50,884 women aged 35-74. Women reported age 5-19 sports/exercise activities and age 10 and 16 unstructured activities. Both hours and MET-hours of activity were considered in association with breast cancer overall, by ER status, and by menopausal status. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox proportional hazards models. 2416 cases were diagnosed during follow-up (mean = 6.4 years). Participation in 7+ hours (vs <1 h) per week of sports/exercise during ages 5-19 was associated with reduced breast cancer risk (HR = 0.75; 95% CI 0.57-0.99). 7+ hours (vs <1 h) per week of unstructured physical activity at age 16, but not age 10, was inversely associated with breast cancer (HR = 0.81; 95% CI 0.70-0.95). Associations were more pronounced for ER+ tumors, especially for activity during the childhood (ages 5-12) p...Continue Reading

References

Jan 15, 1992·American Journal of Epidemiology·L BernsteinB E Henderson
Jan 1, 1993·Medicine and Science in Sports and Exercise·B E AinsworthR S Paffenbarger
Jan 15, 1999·Epidemiology·S GreenlandJ M Robins
Sep 11, 1999·Cancer Causes & Control : CCC·P M MarcusB Sternfeld
Jan 20, 2000·Journal of the National Cancer Institute·J VerloopF E van Leeuwen
Oct 11, 2001·British Journal of Cancer·I M LeeJ E Buring
Jan 11, 2003·American Journal of Epidemiology·Karen SteindorfJenny Chang-Claude
Feb 6, 2003·Medicine and Science in Sports and Exercise·Joan DornSaxon Graham
Feb 14, 2007·Cancer Detection and Prevention·Joanna Kruk
Jun 9, 2007·American Journal of Epidemiology·Clarice R WeinbergDale P Sandler
Feb 1, 2008·Nature Reviews. Cancer·Anne McTiernan
May 15, 2008·Journal of the National Cancer Institute·Sonia S MarutiGraham A Colditz
Jul 11, 2008·Medicine and Science in Sports and Exercise·Kate Ridley, Tim S Olds
Sep 11, 2008·The International Journal of Behavioral Nutrition and Physical Activity·Kate RidleyTim S Olds
Nov 1, 2008·BMC Medical Research Methodology·Ian Shrier, Robert W Platt
Jan 6, 2010·Environmental Health Perspectives·Robert A HiattUNKNOWN Breast Cancer and the Environment Research Centers
Jan 22, 2011·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Christine M Friedenreich
Mar 12, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alexandra J WhiteLisa A DeRoo
Apr 26, 2013·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Frank M Biro, Julianna Deardorff
May 15, 2013·Experimental Cell Research·Holly A MartinsonPepper Schedin
Jun 19, 2013·Breast Cancer Research and Treatment·Lindsay C KobayashiKristan J Aronson
Apr 1, 2014·Breast Cancer Research and Treatment·Caroline E BoekeRulla M Tamimi
Dec 22, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Cécile PizotPhilippe Autier
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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Citations

May 17, 2019·Medicine and Science in Sports and Exercise·Anne McTiernanUNKNOWN 2018 PHYSICAL ACTIVITY GUIDELINES ADVISORY COMMITTEE*
Jun 6, 2019·Breast Cancer Research and Treatment·John D MurphyKatie M O'Brien
Oct 20, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nicole M NiehoffDale P Sandler
Jan 1, 2021·Cancers·Miguel A OrtegaMiguel A Álvarez-Mon
Apr 14, 2021·Journal of Immigrant and Minority Health·Brittany N MoreyScarlett Lin Gomez
Aug 17, 2021·International Journal of Cancer. Journal International Du Cancer·Tianyi WangShelley S Tworoger
Jan 22, 2019·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Xuyu ChenXiaodong Tan

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