Childhood asthma exacerbations and the Arg16 β2-receptor polymorphism: A meta-analysis stratified by treatment

The Journal of Allergy and Clinical Immunology
Steve TurnerPharmacogenomics in Childhood Asthma Consortium

Abstract

The Gly-to-Arg substitution at the 16 position (rs1042713) in the β2-adrenoceptor gene (ADRB2) is associated with enhanced downregulation and uncoupling of β2-receptors. We sought to undertake a meta-analysis to test the hypothesis that there is an interaction between the A allele of rs1042713 (Arg16 amino acid) and long-acting β-agonist (LABA) exposure for asthma exacerbations in children. Children with diagnosed asthma were recruited in 5 populations (BREATHE, Genes-Environments and Admixture in Latino Americans II, PACMAN, the Paediatric Asthma Gene Environment Study, and the Pharmacogenetics of Adrenal Suppression with Inhaled Steroid Study). A history of recent exacerbation and asthma treatment was determined from questionnaire data. DNA was extracted, and the Gly16Arg genotype was determined. Data from 4226 children of white Northern European and Latino origin were analyzed, and the odds ratio for exacerbation increased by 1.52 (95% CI, 1.17-1.99; P = .0021) for each copy of the A allele among the 637 children treated with inhaled corticosteroids (ICSs) plus LABAs but not for treatment with ICSs alone (n = 1758) or ICSs plus leukotriene receptor antagonist (LTRAs; n = 354) or ICSs plus LABAs plus LTRAs (n = 569). The use ...Continue Reading

References

Jul 1, 1995·American Journal of Respiratory Cell and Molecular Biology·S A GreenS B Liggett
Nov 29, 2002·American Journal of Respiratory and Critical Care Medicine·Graeme P CurrieBrian J Lipworth
Jul 14, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S W TurnerP N Le Souëf
Oct 27, 2004·Lancet·Elliot IsraelUNKNOWN National Heart, Lung, and Blood Institute's Asthma Clinical Research Network
Nov 24, 2004·American Journal of Respiratory and Critical Care Medicine·Shweta ChoudhryEsteban González Burchard
Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Stanley J SzeflerLynn M Taussig
Apr 30, 2005·Thorax·I P Hall, J D Blakey
Aug 15, 2008·Archives of Disease in Childhood·S TurnerD Price
Aug 4, 2009·Genome Research·David H AlexanderKenneth Lange
Aug 12, 2009·Pharmacogenomics·Ellen S KosterAnke Hilse Maitland-van der Zee
Nov 13, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Yaron FinkelsteinMichael Shannon
Jun 1, 2010·BMC Bioinformatics·Reedik Mägi, Andrew P Morris
Jul 14, 2010·American Journal of Respiratory and Critical Care Medicine·Anna A P H Vaessen-VerberneUNKNOWN COMBO Study Group
Dec 8, 2010·BMC Medical Research Methodology·Stephen W TurnerDonald Macgregor
Sep 10, 2011·Pediatric Pulmonology·Christopher L CarrollCraig M Schramm
Nov 7, 2012·Clinical Science·Brian J LipworthSomnath Mukhopadhyay
Apr 4, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Verónica GiubergiaLilien Chertkoff
Jun 12, 2013·American Journal of Respiratory and Critical Care Medicine·Katherine K NishimuraEsteban G Burchard
Dec 29, 2013·The Journal of Allergy and Clinical Immunology·Victor E Ortega, Deborah A Meyers
Nov 8, 2014·Clinical Endocrinology·Daniel B HawcuttRosalind L Smyth
Jan 24, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S J H VijverbergA H Maitland-van der Zee

❮ Previous
Next ❯

Citations

May 5, 2016·Paediatric Drugs·Hedy MaagdenbergAnke H Maitland-van der Zee
Jul 28, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G Roberts
Dec 17, 2016·The World Allergy Organization Journal·Tara F Carr, Eugene Bleecker
Mar 16, 2017·Allergy, Asthma & Immunology Research·Heung Woo Park, Kelan G Tantisira
Jun 24, 2017·Pharmacogenomics·Niloufar FarzanAnke H Maitland-van der Zee
Mar 13, 2018·Expert Opinion on Drug Metabolism & Toxicology·Mario CazzolaPaola Rogliani
Apr 28, 2018·Pharmacogenomics·Elise M A SlobAnke-Hilse Maitland-van der Zee
May 23, 2018·Pharmacogenomics·Steve TurnerOn Behalf Of The Pharmacogenomics In Childhood Asthma Consortium
Nov 9, 2017·Expert Review of Respiratory Medicine·Susanne J H VijverbergAnke H Maitland-van der Zee
Jul 12, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Elise M A SlobAnke H Maitland-van der Zee
Oct 20, 2018·Current Opinion in Pulmonary Medicine·Esther Herrera-LuisMaria Pino-Yanes
Jan 17, 2019·Current Opinion in Allergy and Clinical Immunology·Elise M SlobMariëlle W Pijnenburg
Oct 21, 2017·The European Respiratory Journal·Inke R KönigMatthias V Kopp
Mar 15, 2019·Pediatric Pulmonology·Monica TangJason E Lang
Nov 7, 2019·Journal of Clinical Medicine·Leila KarimiKatia M C Verhamme
Feb 9, 2020·The Clinical Respiratory Journal·Almira AkparovaRakhmetkazhi Bersimbaev
Dec 19, 2019·Current Opinion in Allergy and Clinical Immunology·Tunn Ren TayMark Hew
Sep 5, 2019·Thorax·Truls Sylvan IngebrigtsenBørge G Nordestgaard
Nov 2, 2016·Current Opinion in Pulmonary Medicine·Elin T G Kersten, Gerard H Koppelman
May 15, 2018·The Journal of Clinical Endocrinology and Metabolism·Kim Zillo RokampUlrik Pedersen-Bjergaard
Aug 3, 2018·Pediatric Allergy, Immunology, and Pulmonology·Amelia LicariGiorgio Ciprandi
Apr 21, 2019·Allergy·Olga IvanovaAnke H Maitland-van der Zee
Mar 1, 2017·Pharmacogenomics·Susanne Jh VijverbergAnke-Hilse Maitland-van der Zee
Feb 7, 2018·Current Opinion in Allergy and Clinical Immunology·Louise Fleming
Dec 19, 2019·Pharmacological Reviews·M G MateraM Cazzola
Jan 28, 2020·Current Opinion in Allergy and Clinical Immunology·Korneliusz GolebskiUNKNOWN PERMEABLE consortium
Jan 17, 2020·Seminars in Immunopathology·Mahmoud I Abdel-AzizAnke H Maitland-van der Zee
Jan 24, 2020·The New England Journal of Medicine·Michael E WechslerUNKNOWN NHLBI AsthmaNet
Jan 17, 2019·Clinical and Translational Allergy·Ozlem KeskinOmer Kalayci
Jun 11, 2019·Frontiers in Pharmacology·Jesús Miguel García-MenayaJosé A G Agúndez
Nov 10, 2020·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Theodore F Robles
May 1, 2021·International Journal of Molecular Sciences·Emanuela di PalmoAndrea Pession
Jun 16, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Leila KarimiUNKNOWN PiCA and SysPharmPedia consortia
Mar 12, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Elise M A SlobAnke H Maitland-van der Zee
Jan 23, 2021·The European Respiratory Journal·Tom RufflesSomnath Mukhopadhyay
May 5, 2016·Pharmacogenomics·Thomas R SmithDavid F Kisor

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.