PMID: 12777282Jun 5, 2003Paper

Childhood central nervous system viral infections and adult schizophrenia

The American Journal of Psychiatry
Jaana SuvisaariJouko Lönnqvist

Abstract

An earlier Finnish cohort study suggested that childhood viral CNS infections are associated with a fivefold increased odds of developing schizophrenia in adulthood. The authors sought to replicate this finding. From the archives of the Department of Virology of the National Public Health Institute in Finland, 320 individuals born between 1960 and 1976 who had suffered virologically confirmed CNS infections before their 15th birthdays were identified. Of the infections, 202 had been caused by enteroviruses. The sample was followed up in the 1969-2000 records of the National Hospital Discharge Register of Finland to identify all cases of schizophrenia that emerged. The cumulative incidence of schizophrenia was 0.94% in the whole sample and 0.99% among individuals who had suffered enteroviral infections. These rates are comparable to that found in the general population. Childhood viral CNS infections were not associated with increased risk of schizophrenia.

Citations

Oct 4, 2008·Schizophrenia Bulletin·Holger J SørensenSarnoff A Mednick
May 28, 2010·International Review of Psychiatry·Brendan P Murphy
Sep 18, 2010·Schizophrenia Research·Mark WeiserMichael Davidson
Jul 16, 2008·Journal of Clinical Laboratory Analysis·Sandra Odebrechet Vargas NunesMaria Angelica Ehara Watanabe
Mar 4, 2015·Brain, Behavior, and Immunity·Michael VigoritoSulie L Chang
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Mar 11, 2020·Frontiers in Microbiology·Bo-Shiun ChenShin-Ru Shih
Dec 1, 2019·BMC Infectious Diseases·Jonas GrafPhilipp Albrecht

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