Childhood chronic immune thrombocytopenic purpura (ITP)

Blood Reviews
V Blanchette

Abstract

Chronic immune thrombocytopenic purpura (ITP) develops in approximately 20% of children with acute ITP. Treatment requires differentiating the truly idiopathic state from thrombocytopenias associated with other disorders. Treatment is recommended in cases where platelet counts drop below 20 x 10(9)/L. Therapeutic options include corticosteroids, intravenous immunoglobulin TG(i.v.Ig), and anti-D, as well as splenectomy. The benefits and disadvantages of each modality are reviewed, as well as the management of postsplenectomy failures.

Citations

Oct 30, 2009·Pediatric Hematology and Oncology·Fatih DemircioğluGülersu Irken
Aug 28, 2004·International Journal of Paediatric Dentistry·B VaismanG Ramirez
Nov 18, 2003·British Journal of Haematology·John Lilleyman
Nov 19, 2011·PloS One·Axel C MatzdorffSimone Hummler
Aug 18, 2010·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Sinan AkbayramAhmet Faik Oner
Nov 4, 2004·American Journal of Medical Genetics. Part a·Jeffrey E MingElaine H Zackai
May 12, 2005·American Journal of Medical Genetics. Part a·Jodi D HoffmanJeffrey E Ming
Dec 18, 2009·Cellular and Molecular Life Sciences : CMLS·John W Semple, John Freedman
Jun 21, 2012·Journal of Pediatric Hematology/oncology·Daniela Maria de Mendonça Caldas AmorimLuiz Gonzaga Tone
Jul 16, 2015·Pediatric Blood & Cancer·Manjusha KumarUNKNOWN ITP Consortium of North America

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