PMID: 7014663Apr 1, 1981Paper

Childhood dermatitis herpetiformis. Review of the new aspects and report of a case

Journal of the American Academy of Dermatology
B SafaiM Lewin

Abstract

Dermatitis herpetiformis (DH) of linear IgA type occurred in a 6-month-old boy shortly after initiating sulfisoxazole therapy for a urinary tract infection. Generalized pruritic bullae on erythematous bases were present on his trunk and extremities. There were no clinical or laboratory findings suggestive of gastrointestinal involvement. Direct immunofluorescent studies of skin biopsies taken early in the course of the disease and while the child was on systemic corticosteroid therapy were negative. Eventually a linear deposition of IgA at the dermoepidermal junction of involved skin on direct immunofluorescence was demonstrated. No circulating antibodies to the basement membrane were found. Because of close proximity of the initiation of sulfisoxazole (Gantrisin) therapy and the eruption of the initial bullous lesions, this case also presents an interesting diagnostic and therapeutic problem. Negative assays of lymphocyte migration inhibition factor (LMIF) to sulfisoxazole indicated that the likelihood of a hypersensitivity reaction to sulfa drugs was slight. The patient's clinical response to dapsone therapy was dramatic. The conflicting views of subepidermal bullous dermatosis of childhood and the difficulties in confirming ...Continue Reading

Citations

Jun 1, 1993·Pediatric Dermatology·L L HruzaG B Mallory
Aug 1, 1982·The Australasian Journal of Dermatology·M RogersG Cains
Dec 1, 1994·Pediatric Dermatology·T W McGovern, S D Bennion
Aug 4, 2001·The Annals of Pharmacotherapy·J del PozoE Fonseca

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