Childhood energy intake is associated with nonalcoholic fatty liver disease in adolescents.

The Journal of Nutrition
Emma L AndersonDebbie A Lawlor

Abstract

Greater adiposity is an important risk factor for nonalcoholic fatty liver disease (NAFLD). Thus, it is likely that dietary intake is involved in the development of the disease. Prospective studies assessing the relation between childhood dietary intake and risk of NAFLD are lacking. This study was designed to explore associations between energy, carbohydrate, sugar, starch, protein, monounsaturated fat, polyunsaturated fat, saturated fat, and total fat intake by youth at ages 3, 7, and 13 y and subsequent (mean age: 17.8 y) ultrasound scan (USS)-measured liver fat and stiffness and serum alanine aminotransferase, aspartate aminotransferase, and γ-glutamyltransferase. We assessed whether observed associations were mediated through fat mass at the time of outcome assessment. Participants were from the Avon Longitudinal Study of Parents and Children. Trajectories of energy and macronutrient intake from ages 3-13 y were obtained with linear-spline multilevel models. Linear and logistic regression models examined whether energy intake and absolute and energy-adjusted macronutrient intake at ages 3, 7, and 13 y were associated with liver outcomes. Energy intake at all ages was positively associated with liver outcomes; for example, ...Continue Reading

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Citations

Oct 28, 2015·International Journal of Cancer. Journal International Du Cancer·Esther ZimmermannJennifer L Baker
Mar 9, 2021·Obesity Science & Practice·Gertraud MaskarinecJohn A Shepherd

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