Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth.

Environmental Health Perspectives
Malene BoasKatharina M Main

Abstract

Phthalates are widely used chemicals, and human exposure is extensive. Recent studies have indicated that phthalates may have thyroid-disrupting properties. We aimed to assess concentrations of phthalate metabolites in urine samples from Danish children and to investigate the associations with thyroid function, insulin-like growth factor I (IGF-I), and growth. In 845 children 4-9 years of age, we determined urinary concentrations of 12 phthalate metabolites and serum levels of thyroid-stimulating hormone, thyroid hormones, and IGF-I. Phthalate metabolites were detected in all urine samples, of which monobutyl phthalate was present in highest concentration. Phthalate metabolites were negatively associated with serum levels of free and total triiodothyronine, although statistically significant primarily in girls. Metabolites of di(2-ethylhexyl) phthalate and diisononyl phthalate were negatively associated with IGF-I in boys. Most phthalate metabolites were negatively associated with height, weight, body surface, and height gain in both sexes. Our study showed negative associations between urinary phthalate concentrations and thyroid hormones, IGF-I, and growth in children. Although our study was not designed to reveal the mechani...Continue Reading

References

Dec 1, 1986·Environmental Health Perspectives·R H HintonJ W Bridges
Feb 1, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R PoonI Chu
Oct 15, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F A ArcadiG Costa
Dec 2, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·L E GrayL Parks
Jun 19, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K NysomK F Michaelsen
Sep 7, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·John C O'ConnorGregory S Ladics
Feb 13, 2003·Molecular and Cellular Endocrinology·Akinori IshiharaKiyoshi Yamauchi
Mar 17, 2004·Reproductive Toxicology·Rochelle W TylJohn H Butala
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Pia Skov HansenLaszlo Hegedüs
Dec 4, 2004·International Journal of Hygiene and Environmental Health·Kerstin BeckerDetlef Ullrich
Dec 8, 2004·Environmental Health Perspectives·Russ HauserAntonia M Calafat
Feb 22, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Toyohito Tanaka
Apr 15, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher J BowmanPaul M D Foster
Feb 10, 2006·International Journal of Andrology·Ted Schettler
Apr 29, 2006·European Journal of Endocrinology·Malene BoasKatharina M Main
Jul 13, 2006·Risk Analysis : an Official Publication of the Society for Risk Analysis·Matthias WormuthKonrad Hungerbühler
Mar 21, 2007·Environmental Health Perspectives·Mary S WolffAntonia M Calafat
Jul 20, 2007·Environmental Health Perspectives·John D MeekerRuss Hauser
Aug 21, 2007·Human Reproduction·Po-Chin HuangChing-Chang Lee
Nov 13, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Manori J SilvaAntonia M Calafat
Dec 12, 2007·International Journal of Andrology·Matthias Wittassek, Jürgen Angerer
Jan 16, 2008·International Journal of Andrology·Nadeem Rezaq JanjuaAnna-Maria Andersson
Feb 5, 2008·Pediatrics·Sheela SathyanarayanaShanna H Swan
Apr 1, 1996·Trends in Endocrinology and Metabolism : TEM·S Feld, R Hirschberg
May 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Han LinMatthew P Hardy
Aug 19, 2008·Environmental Health Perspectives·Mary S WolffAntonia M Calafat
Dec 20, 2008·European Journal of Endocrinology·P Iglesias, J J Díez
Jul 16, 2009·The Journal of Clinical Endocrinology and Metabolism·Malene BoasKatharina M Main

❮ Previous
Next ❯

Citations

Nov 28, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Katrine Tefre de Renzy-MartinTina Kold Jensen
Jan 8, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Hanne FrederiksenAnna-Maria Andersson
Jan 7, 2014·International Journal of Hygiene and Environmental Health·Michael CallesenTina Kold Jensen
Jul 20, 2014·Early Human Development·Kinga PolanskaWojciech Hanke
Sep 22, 2011·Environmental Health : a Global Access Science Source·Christine Wohlfahrt-VejeHelle R Andersen
Feb 23, 2013·Current Opinion in Pediatrics·Joseph M BraunRuss Hauser
Aug 31, 2011·Thyroid : Official Journal of the American Thyroid Association·Francoise Brucker-DavisPatrick Fenichel
Jul 27, 2012·Environmental Health Perspectives·Ulla Nordström JoensenNiels Jørgensen
Feb 5, 2016·Environmental Science and Pollution Research International·Clélie BraouezecMarie-Jeanne Teil
Nov 29, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Tzung-Hai YenJa-Liang Lin
Dec 15, 2015·Environmental Science & Technology·Antonis MyridakisEuripides G Stephanou
Mar 27, 2013·International Journal of Hygiene and Environmental Health·Hanne FrederiksenLisbeth E Knudsen
Jun 29, 2012·Neurotoxicology·Camille A MartinaShanna H Swan
Oct 11, 2011·International Journal of Hygiene and Environmental Health·Monika Kasper-SonnenbergMichael Wilhelm
Jun 15, 2015·Environment International·Antonis MyridakisEuripides G Stephanou
Aug 28, 2015·Environment International·Lauren E JohnsJohn D Meeker
Mar 21, 2012·International Journal of Andrology·H FrederiksenA Juul
May 23, 2012·International Journal of Andrology·Mikkel G MieritzAnders Juul
May 9, 2012·Indoor Air·F CarlstedtC-G Bornehag
Sep 16, 2011·Journal of Thyroid Research·Marie-Louise Hartoft-NielsenUlla Feldt-Rasmussen
Sep 18, 2013·Chemosphere·Ryan C LewisMartha Maria Téllez-Rojo
Jan 15, 2014·Critical Reviews in Toxicology·Michael GoodmanDonald R Mattison
Jul 15, 2015·International Journal of Hygiene and Environmental Health·Jia-Woei HouMei-Lien Chen
Jan 19, 2015·Reproductive Biology and Endocrinology : RB&E·Lauren E JohnsJohn D Meeker
Dec 17, 2014·Environmental Health : a Global Access Science Source·Marijke de CockMargot van de Bor
Apr 19, 2015·International Journal of Hygiene and Environmental Health·Yu Ait BamaiReiko Kishi
Sep 24, 2011·Molecular and Cellular Endocrinology·Malene BoasKatharina M Main
Sep 26, 2014·Environmental Science and Pollution Research International·Wen-Long WangHong-Ying Hu

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.