Childhood immune thrombocytopenic purpura: diagnosis and management

Hematology/oncology Clinics of North America
V Blanchette, P H Bolton-Maggs

Abstract

Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by a low circulating platelet count caused by destruction of antibody-sensitized platelets in the reticuloendothelial system. ITP can be classified as childhood versus adult, acute versus chronic, and primary versus secondary. Persistence of thrombocytopenia defines the chronic form of the disorder. Secondary causes of ITP include collagen vascular disorders, immune deficiencies, and some chronic infections. This review focuses on the diagnosis and management of children who have acute and chronic ITP. Emphasis is placed on areas of controversy and new therapies.

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Oct 18, 2012·Journal of Pediatric Hematology/oncology·John A D'OrazioNina Farhoudi
Jul 26, 2014·Emergency Medicine Clinics of North America·Shane KapplerAutumn Graham
Jan 7, 2014·European Journal of Pediatrics·Veerle Labarque, Chris Van Geet
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