Childhood immune thrombocytopenic purpura

Blood Reviews
Diane J Nugent

Abstract

Childhood immune thrombocytopenic purpura (ITP) is acute and generally seasonal in nature, suggesting that infectious or environmental agents may trigger the immune response to produce platelet-reactive autoantibodies 4 to 8 weeks following an infection. In general, the patient is well apart from the diffuse bruising and petechiae indicative of a profound thrombocytopenia. Over a period of 6 months, the thrombocytopenia resolves in approximately 85% of children, while the remaining 15% with persistent platelet consumption are designated as chronic ITP patients. The peak age of acute ITP is 2 to 5 years of age, a period when children experience the greatest frequency of viral infections. Children with the chronic form of ITP mirror the adult phenotype, in that females predominate, and there is no seasonal fluctuation of the disease. Evidence from our laboratory suggests that the activated platelet itself may play a role in perpetuating autoantibody production and immune dysregulation associated with ITP. Current data on lymphocyte studies and cytokine alterations noted in response to the variety of regimens used in children with ITP suggest that acute ITP is accompanied by autoantibodies to GPIb and a cytokine profile that is pr...Continue Reading

References

Mar 1, 1977·American Journal of Diseases of Children·P D McClure
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Jun 3, 1999·Transfusion Science·T Kühne, P Imbach
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Dec 29, 2000·Cellular and Molecular Life Sciences : CMLS·A D FarrisJ McCluskey

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Citations

Sep 6, 2007·Pediatric Hematology and Oncology·Gordana Jakovljević, Srdana Culić
Aug 28, 2004·International Journal of Paediatric Dentistry·B VaismanG Ramirez
May 4, 2007·International Journal of Laboratory Hematology·W U Chang-LinL V Xue-Wen
Jan 18, 2013·Human Vaccines & Immunotherapeutics·Valerio CecinatiSusanna Esposito
Jan 31, 2004·Pediatric Blood & Cancer·Claudio SandovalSomasundaram Jayabose
Jun 12, 2010·Journal of Pediatric Hematology/oncology·Elpis MantadakisAthanassios Chatzimichael
Oct 18, 2012·Journal of Pediatric Hematology/oncology·John A D'OrazioNina Farhoudi
Feb 12, 2004·The Pediatric Infectious Disease Journal·Hector NuevoLícia M O Moreira
Jun 21, 2012·Journal of Pediatric Hematology/oncology·Daniela Maria de Mendonça Caldas AmorimLuiz Gonzaga Tone
Jul 25, 2021·International Journal of Molecular Sciences·Iason ThomasAthanasia Mouzaki

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