Childhood inflammatory and metabolic disease following exposure to antibiotics in pregnancy, antenatally, intrapartum and neonatally

F1000Research
Ronald F LamontJan Stener Jørgensen

Abstract

Background: There are concerns that the use of antibiotics before, during or immediately after pregnancy may have adverse effects on the neonatal gut microbiome and adversely affect the development of the infant immune system, leading to the development of childhood allergy, asthma, atopic disease and obesity. Methods: In this narrative review, we have explored a number of hypotheses, including the "Barker hypothesis", the "hygiene hypothesis", the link between inflammation and metabolic disease, and the influence of the neonatal gut microbiota on the development of the immune system in infants. Results: We found evidence to link the use of antibiotics before, during or immediately after pregnancy with an increased risk of childhood allergy, asthma, atopy and obesity. Conclusions: Although we found robust evidence to link antibiotic use in pregnancy with obesity and an "allergic triad" of asthma, eczema and hay fever, care must be taken when interpreting the findings because of the lack of adjustment for confounding variables in published studies. These may be (i) whether or not the mother had the same outcome variable (for example, asthma) as the infant, for which the mother may have received the antibiotics; (ii) the indicati...Continue Reading

References

Nov 18, 1989·BMJ : British Medical Journal·D P Strachan
Jul 9, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N SudoC Kubo
Sep 17, 2002·American Journal of Respiratory and Critical Care Medicine·Tricia M McKeeverRichard Hubbard
Dec 31, 2003·Molecular Immunology·Bruce Beutler
Jun 18, 2004·Immunological Reviews·Vincent Leclerc, Jean-Marc Reichhart
Nov 6, 2004·Journal of Clinical Microbiology·Françoise JauréguyFlorence Doucet-Populaire
Feb 4, 2005·The New England Journal of Medicine·Huong Q NguyenJane F Seward
May 3, 2005·The Journal of Clinical Investigation·Kathryn E Wellen, Gökhan S Hotamisligil
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Sep 9, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto Romero
Mar 9, 2010·Italian Journal of Pediatrics·Carlo CaffarelliUNKNOWN EWGPAG
Jan 22, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·R F LamontR Romero
Mar 1, 2012·Pediatrics·UNKNOWN Section on Breastfeeding
Sep 15, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Henrik T ChristesenJan S Jørgensen
Nov 13, 2012·The Journal of Pediatrics·Lone Graff StensballeHans Bisgaard
Dec 6, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Henrik T ChristesenJan S Jørgensen
Jan 26, 2013·Epidemiology·Johanna MetsäläSuvi M Virtanen
Apr 24, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A C VidalC Hoyo
Jun 21, 2013·The British Journal of Dermatology·T TsakokC Flohr
Sep 7, 2013·Science·Vanessa K RidauraJeffrey I Gordon
Oct 11, 2013·The American Journal of Clinical Nutrition·Bich TranRachel E Neale
Oct 29, 2013·Advances in Experimental Medicine and Biology·Sharon Croisant
Feb 18, 2014·The Journal of Allergy and Clinical Immunology·Agnes M M Sonnenschein-van der VoortLiesbeth Duijts
Apr 24, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·A BroeP Damkier
Jun 20, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J MetsäläS M Virtanen
Jul 30, 2014·The Lancet. Respiratory Medicine·Jakob StokholmHans Bisgaard
Oct 10, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·N T MuellerA Rundle
Oct 10, 2014·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·I Asher, N Pearce
Dec 24, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Brittany LapinVictoria Persky
Jan 9, 2015·Journal of the American Board of Family Medicine : JABFM·Debra L WohlKaitlyn Tyrie
Jan 13, 2015·Trends in Molecular Medicine·Noel T MuellerMaria G Dominguez-Bello
Jan 15, 2015·Allergy and Asthma Proceedings·Giuliana FerranteStefania La Grutta
Feb 24, 2015·Lancet·Tim LobsteinKlim McPherson
Jul 17, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A MorV Ehrenstein
Sep 29, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·M B AzadUNKNOWN CHILD Study Investigators
Nov 21, 2015·Acta Obstetricia Et Gynecologica Scandinavica·Christina Anne VinterJan Stener Jørgensen
Feb 2, 2016·Nature Medicine·Maria G Dominguez-BelloJose C Clemente
Feb 26, 2016·BMJ : British Medical Journal·Aubrey J CunningtonJonathan Darby
May 1, 2016·Trends in Endocrinology and Metabolism : TEM·Gregor Reid

❮ Previous
Next ❯

Citations

Sep 25, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Mark A UnderwoodCharles L Bevins
Jul 28, 2020·International Journal of Molecular Sciences·Rosita GabbianelliJoan G Lalor
Nov 18, 2020·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Philip O Anderson
Dec 19, 2020·Microorganisms·Mohammed AmirMelody Y Zeng
Oct 30, 2020·Frontiers in Immunology·Sabine Pirr, Dorothee Viemann
May 4, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Anne Gaml-SørensenCecilia H Ramlau-Hansen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

© 2021 Meta ULC. All rights reserved