Childhood neglect is associated with reduced corpus callosum area

Biological Psychiatry
Martin H TeicherSusan L Andersen

Abstract

Childhood abuse has been associated with abnormalities in brain development, particularly corpus callosum (CC) morphology. The impact of neglect has not been assessed, though it is the most prevalent form of childhood maltreatment. Regional CC area was measured from magnetic resonance imaging scans in 26 boys and 25 girls admitted for psychiatric evaluation (28 with abuse or neglect) and compared with CC area in 115 healthy control subjects. Data were analyzed by multivariate analysis of covariance, with age and midsagittal area as covariates. Total CC area of the abused/neglected patients was 17% smaller than in control subjects (p =.0001) and 11% smaller than in psychiatric patients who had not been abused or neglected (contrast group; p =.01). Control subjects and the contrast group did not differ in total CC area. Neglect was the strongest experiential factor and was associated with a 15%-18% reduction in CC regions 3, 4, 5, and 7 (all p <.02). In contrast, sexual abuse seemed to be the strongest factor associated with reduced CC size in girls. These data are consistent with animal research that demonstrated reduced CC size in nursery-reared compared with semi-naturally reared primates. Early experience might also affect th...Continue Reading

References

Jul 1, 1986·Journal of the American Academy of Child Psychiatry·G A RogenessS K Hoppe
Jan 1, 1995·The Journal of Neuropsychiatry and Clinical Neurosciences·F SchifferA C Papanicolaou
Jan 1, 1993·The Journal of Neuropsychiatry and Clinical Neurosciences·Y ItoH A Gelbard
Jul 1, 1997·Psychological Medicine·M B SteinB McClarty
Aug 26, 1998·The Journal of Neuropsychiatry and Clinical Neurosciences·Y ItoE Ackerman
Jun 1, 1999·Biological Psychiatry·M D De BellisN D Ryan
Jul 26, 2002·The Psychiatric Clinics of North America·Martin H TeicherCarryl P Navalta
Oct 16, 2002·Nature Neuroscience·Mark W GilbertsonRoger K Pitman
May 7, 2003·Neuroscience and Biobehavioral Reviews·Michael D De Bellis, Matcheri S Keshavan

❮ Previous
Next ❯

Citations

Jun 3, 2009·Archives of General Psychiatry·Simona SpinelliElliot Stein
Nov 26, 2010·Psychopharmacology·Dawson W Hedges, Fu Lye Woon
Oct 11, 2011·Brain Structure & Function·Alvaro DuqueArthur A Simen
Jun 5, 2012·Journal of Neural Transmission·Brigitte DahmenKerstin Konrad
Jul 20, 2011·European Child & Adolescent Psychiatry·Corina BenjetMaria Elena Medina-Mora
Apr 29, 2010·Current Psychiatry Reports·Jana Mauchnik, Christian Schmahl
Sep 27, 2012·Current Psychiatry Reports·Marissa CummingsPhilip V Scribano
Sep 19, 2009·Journal of the Chinese Medical Association : JCMA·Kai-Lin HuangYing-Shue Chen
Jun 6, 2008·Psychological Medicine·V V McCutcheonN G Martin
Aug 9, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Negar FaniKerry J Ressler
May 23, 2006·Nature Reviews. Neuroscience·R Douglas Fields, Geoffrey Burnstock
Apr 28, 2006·Current Opinion in Psychiatry·Isabel PazGerry Byrne
Dec 20, 2007·The Journal of Nervous and Mental Disease·Noriyuki KitayamaJ Douglas Bremner
Nov 13, 2010·Addiction Biology·Emre BoraDan I Lubman
Aug 4, 2006·Psychiatry and Clinical Neurosciences·Taro EndoToshiyuki Someya
Jan 22, 2009·Psychiatry and Clinical Neurosciences·Andrea Parolin JackowskiJoan Kaufman
Aug 25, 2007·Annual Review of Clinical Psychology·Dante Cicchetti, Sheree L Toth
Aug 25, 2007·Annual Review of Clinical Psychology·Adrian Raine
Nov 12, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·R Douglas Fields
Feb 18, 2010·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Vivia V McCutcheonNicholas G Martin
Oct 23, 2010·Journal of Psychiatry & Neuroscience : JPN·Judith K DanielsRuth A Lanius
Mar 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anthony Steven DickSteven L Small
Aug 11, 2010·Pediatrics·Jennie G NollPenelope K Trickett
Jan 5, 2011·Frontiers in Bioscience (Scholar Edition)·Nicole R Herring, Christine Konradi
Oct 29, 2013·Human Molecular Genetics·Hongqin XuHuiping Zhang
Apr 29, 2014·Neuroscience and Biobehavioral Reviews·Lei LiQiyong Gong
Apr 5, 2013·European Child & Adolescent Psychiatry·Mirjam A W Rinne-AlbersRobert R J M Vermeiren
Sep 17, 2014·Child Abuse & Neglect·Howard DubowitzNancy D Kellogg
Jan 31, 2016·Biochimica Et Biophysica Acta·Hyesook YoonIsobel A Scarisbrick
Jun 4, 2016·Archives of Psychiatric Nursing·Carolyn M Fratto
Feb 3, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Martin H Teicher, Jacqueline A Samson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.