Childhood neglect is associated with corticostriatal circuit dysfunction in bipolar disorder adults.

Psychiatry Research
Yi-Ting HsiehPo See Chen

Abstract

Bipolar disorder (BD) is characterized with cognitive impairment, which may be mediated by corticostriatal dysfunction. Here we examined whether history of childhood trauma, a risk factor for BD, was linked to corticostriatal dysfunction in BD patients. Furthermore, the possible associations between childhood trauma and cognitive impairment were examined. Thirty-eight BD participants who met the DSM-IV diagnostic criteria were enrolled. Childhood trauma was identified via the Childhood Trauma Questionnaire (CTQ). Participants completed the Wisconsin Card-Sorting Test (WCST). Resting-state functional magnetic resonance imaging (rsfMRI) was performed in participants using a 3T scanner. Bilateral caudate to whole-brain functional connectivity (FC) were analyzed, and childhood trauma was entered as a regressor of interest when controlling for age. Results showed the level of physical neglect was negatively correlated with left-caudate-seed FC to the frontoparietal network, including the right supramarginal gyrus, left inferior parietal lobule, right middle frontal gyrus, and right superior parietal lobule. The level of physical neglect was also negatively correlated with WCST performance. And the left-caudate-seed FCs to the fronto...Continue Reading

References

Mar 1, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·D P BernsteinL Handelsman
Nov 28, 1997·Schizophrenia Research·P StrattaA Rossi
May 23, 2001·Psychiatry Research·J K ZubietaB J Giordani
Jul 2, 2003·The American Journal of Psychiatry·Hilary P BlumbergBradley S Peterson
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Sep 2, 2005·The American Journal of Psychiatry·Stephen M StrakowskiJames C Eliassen
Apr 18, 2006·Biological Psychiatry·Ronald A CohenLeanne M Williams
May 9, 2006·Journal of Affective Disorders·Lucy J RobinsonP Brian Moore
Jan 17, 2008·The American Journal of Psychiatry·Andrew M McIntoshStephen M Lawrie
Apr 11, 2008·Cerebral Cortex·A Di MartinoM P Milham
May 10, 2008·Neuron·Maurizio CorbettaGordon L Shulman
Mar 10, 2009·Bipolar Disorders·Aliza P WingoRoss J Baldessarini
Sep 25, 2009·Schizophrenia Bulletin·Helen L FisherCraig Morgan
Oct 6, 2009·Journal of Affective Disorders·Scott A LangeneckerMelvin G McInnis
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael KoenigsJordan Grafman
Sep 29, 2011·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Marisa N SpannHilary P Blumberg
Dec 8, 2011·Archives of Pediatrics & Adolescent Medicine·Erin E EdmistonHilary P Blumberg
Mar 30, 2012·Frontiers in Human Neuroscience·Heledd Hart, Katya Rubia
Nov 12, 2015·Journal of Traumatic Stress·Kate Ryan KuhlmanNestor L Lopez-Duran
Nov 28, 2015·Human Brain Mapping·Roberto Goya-MaldonadoOliver Gruber
Dec 18, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Laurel S MorrisValerie Voon
Dec 26, 2015·Journal of the American Academy of Child and Adolescent Psychiatry·Marie-Claude GeoffroyChris Power
Dec 29, 2015·Psychiatry Research·David F MarshallScott A Langenecker
Jan 15, 2016·International Journal of Bipolar Disorders·Monica AasBruno Etain
Apr 20, 2016·Brain Imaging and Behavior·Yann QuidéMelissa J Green
May 3, 2016·Journal of Affective Disorders·Julia Souza-QueirozJosselin Houenou
May 14, 2016·Journal of Affective Disorders·Roscoe O BradyMatcheri Keshavan
Jul 1, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jeffrey M SpielbergAmit Anand
Aug 18, 2016·Neuroscience and Biobehavioral Reviews·Hadas Erel, Daniel A Levy
Jul 12, 2017·Bipolar Disorders·Esther JiménezAntoni Benabarre
Dec 1, 2017·Brain : a Journal of Neurology·Sara De SimoniDavid J Sharp
Dec 19, 2017·Human Brain Mapping·Indira TendolkarGuillén Fernández
Jun 29, 2018·Journal of Psychiatry & Neuroscience : JPN·Sabrina K SyanLuciano Minuzzi
Apr 10, 2019·Proceedings of the National Academy of Sciences of the United States of America·Meichen YuYvette I Sheline

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.