Childhood Obesity and Cancer Risk in Adulthood.

Current Obesity Reports
Paul WeiheSusann Weihrauch-Blüher

Abstract

The purpose of this review is to summarize our current understanding of the association between childhood obesity and cancer risk later in life. Adipose tissue secrets a variety of adipocytokines, and expression and/or secretion rate of most of them seems to be increased or dysregulated in obesity. In addition, obesity leads to increased secretion of proinflammatory cytokines such as interferon-γ (IFN-γ), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α), which promotes an infiltration of inflammatory immune cells into adipose tissue. This process may facilitate a state of "subclinical inflammation" (metaflammation) and may lead to the development of the metabolic syndrome (MetS), starting as early as during childhood. In addition, several oncogenes have been linked to inflammation and cancer development via different pathways, and several types of tumors need an inflammatory environment before a malignant change occurs. An inflammatory environment seems to promote the proliferation and survival of malignant cells as well as angiogenesis. Natural killer (NK) cells play an important role in this process, as they are able to kill transformed cells without prior sensitization and coordinate subsequent immune responses by p...Continue Reading

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Citations

Dec 30, 2020·Cancers·Ludwig KieselMichael Eichbaum
May 19, 2021·International Journal of Cancer. Journal International Du Cancer·Xuexian FangXinbing Sui
Jun 8, 2021·Journal of Pediatric Orthopedics·Jeffrey R Sawyer
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Aug 17, 2021·International Journal of Cancer. Journal International Du Cancer·Tianyi WangShelley S Tworoger
Aug 28, 2021·Clinical and Experimental Pediatrics·Jieun Lee, Jae Hyun Kim

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