Childhood obesity and the associated rise in cardiometabolic complications.

Nature Metabolism
Sonia CaprioRam Weiss

Abstract

Childhood obesity is one of the most serious global public-health challenges of the twenty-first century. Over the past four decades, the number of children and adolescents with obesity has risen more than tenfold. Worldwide, an increasing number of youth are facing greater exposure to obesity throughout their lives, and this increase will contribute to the early development of type 2 diabetes, fatty liver and cardiovascular complications. Herein, we provide a brief overview of trends in the global shifts in, and environmental and genetic determinants of, childhood obesity. We then discuss recent progress in the elucidation of the central role of insulin resistance, the key element linking obesity and cardiovascular-risk-factor clustering, and the potential mechanisms through which ectopic lipid accumulation leads to insulin resistance and its associated cardiometabolic complications in obese adolescents. In the absence of effective prevention and intervention programs, childhood obesity will have severe public-health consequences for decades to come.

References

May 24, 1990·The New England Journal of Medicine·A J StunkardG E McClearn
May 1, 1996·The Journal of Pediatrics·O Pinhas-HamielP Zeitler
Jun 15, 1996·The Journal of Clinical Investigation·M RodenG I Shulman
Sep 16, 1999·The New England Journal of Medicine·I S FarooqiS O'Rahilly
Oct 13, 1999·The Journal of Pediatrics·J A MorrisonD L Sprecher
Nov 5, 1999·JAMA : the Journal of the American Medical Association·J P Koplan, W H Dietz
Jul 21, 2000·The Journal of Clinical Investigation·G I Shulman
Jul 21, 2000·The Journal of Clinical Investigation·I S FarooqiS O'Rahilly
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
May 29, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·E Miraglia Del GiudiceL Perrone
Sep 21, 2002·Lancet·Cara B EbbelingDavid S Ludwig
Sep 21, 2002·Diabetologia·K N Frayn
Feb 18, 2003·Journal of the American Dietetic Association·Lisa R Young, Marion Nestle
Mar 21, 2003·The New England Journal of Medicine·I Sadaf FarooqiStephen O'Rahilly
Oct 22, 2003·Obesity Research·Robert W Jeffery, Jennifer Utter
Dec 24, 2003·European Journal of Pediatrics·Christian DenzerKurt Widhalm
Mar 31, 2004·The American Journal of Clinical Nutrition·George A BrayBarry M Popkin
Apr 8, 2004·The Journal of Pediatrics·Meg ZellerStephen Daniels
Apr 21, 2004·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·T LobsteinUNKNOWN IASO International Obesity TaskForce
Jun 4, 2004·The New England Journal of Medicine·Ram WeissSonia Caprio
Jan 5, 2005·Pediatrics·David S FreedmanGerald S Berenson
Mar 29, 2005·Diabetes Care·Ram WeissSonia Caprio
Apr 20, 2005·Circulation·Stephen R DanielsChristine L Williams
Jun 16, 2005·JAMA : the Journal of the American Medical Association·Jean-Pierre ChanoineJonathan Hauptman
Dec 6, 2005·Metabolism: Clinical and Experimental·Thomas ReinehrRanier Wunsch
Aug 24, 2006·The Journal of Clinical Endocrinology and Metabolism·Jeffrey C WinerSonia Caprio
Oct 4, 2006·Pediatrics·Jeffrey B SchwimmerCynthia Behling
May 15, 2007·Nature Genetics·Christian DinaPhilippe Froguel
Sep 29, 2007·International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity·Youfa Wang, Tim Lobstein
Dec 7, 2007·The New England Journal of Medicine·David S Ludwig
Dec 29, 2007·Journal of Pediatric Gastroenterology and Nutrition·A O ScheimannW Klish

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Citations

Aug 23, 2020·Environmental Health and Preventive Medicine·Ana Paula SehnCézane Priscila Reuter
Mar 7, 2021·International Journal of Environmental Research and Public Health·Michelle KlerksLuis Manuel Sanchez-Siles
Apr 24, 2021·Frontiers in Endocrinology·Serena ScapaticciCosimo Giannini
Jul 3, 2021·Nutrients·Rafael Molina-LuqueGuillermo Molina-Recio
Aug 5, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Sohier YahiaNanees Salem

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genotyping
gastric bypass

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