Childhood obesity: immune response and nutritional approaches

Frontiers in Immunology
Thea Magrone, Emilio Jirillo

Abstract

Childhood obesity is characterized by a low-grade inflammation status depending on the multicellular release of cytokines, adipokines, and reactive oxygen species. In particular, the imbalance between anti-inflammatory T regulatory cells and inflammatory T helper 17 cells seems to sustain such a phlogistic condition. Alterations of gut microbiota since childhood also contribute to the maintenance of inflammation. Therefore, besides preventive measures and caloric restrictions, dietary intake of natural products endowed with anti-oxidant and anti-inflammatory activities may represent a valid interventional approach for preventing and/or attenuating the pathological consequences of obesity. In this regard, the use of prebiotics, probiotics, polyphenols, polyunsaturated fatty acids, vitamins, and melatonin in human clinical trials will be described.

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Citations

Oct 21, 2015·Pediatric Research·M Karen Campbell
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Aug 10, 2020·Jornal de pediatria·Carlos Alberto Nogueira-de-AlmeidaFábio da V Ued

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Methods Mentioned

BETA
transgenic

Software Mentioned

HELENA
MedDiet

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