Childhood obesity leads to adult type 2 diabetes and coronary artery diseases: A 2-sample mendelian randomization study

Medicine
Xuqian FangPeizhan Chen

Abstract

Observational studies have reported that childhood obesity is positively associated with risks of type 2 diabetes (T2D) and coronary artery disease (CAD) in adults; however, whether this association is causal is still unclear. In the present study, we conducted the 2-sample Mendelian randomization (MR) studies to investigate whether childhood obesity is causally associated with T2D and CAD in adults.Seven single-nucleotide polymorphisms (SNPs) that significantly associated with childhood obesity were used as instrumental variables. The 2-sample MR analyses were performed with the summary-level data of large-sample genome-wide association studies to evaluate the causal effects of childhood obesity on adult T2D and CAD and the levels of cardiometabolic traits.The 2-sample MR analyses suggested that each 1-unit increase in the log-odds of having childhood obesity was causally associated with an increased risk of adult T2D (odds ratio [OR] = 1.16, 95% confidential interval [CI] = 1.06-1.28; P = 1.0 × 10) and CAD (OR = 1.07, 95% CI = 1.02-1.12; P = 4.0 × 10) based on the inverse-variance weighted method. The MR analyses also suggested that childhood obesity was positively associated with the levels of adult body mass index, waist ci...Continue Reading

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Citations

Mar 7, 2020·BMC Research Notes·Omid EslamiFarzad Shidfar
Oct 22, 2020·Obesity Science & Practice·Megan M OberleAaron S Kelly
Nov 25, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Sonali MalhotraVibha Singhal
Dec 15, 2020·Health Promotion Perspectives·Georgianna MannMegan Partacz
Jan 22, 2021·The Nurse Practitioner·Michelle D GrafMary S Dietrich
Mar 30, 2021·International Journal of General Medicine·Amy W RachfalStanley S Schwartz
Oct 19, 2021·Frontiers in Nutrition·Kacper MarunowskiMaciej Piskunowicz

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Software Mentioned

R
MendelianRandomization
TwoSampleMR

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