Childhood-onset schizophrenia: an open-label study of olanzapine in adolescents

Journal of the American Academy of Child and Adolescent Psychiatry
Sanjiv KumraJ L Rapoport

Abstract

Olanzapine, a potent 5-HT2a/2c, dopamine D1D2D4 antagonist with anticholinergic activity, has a profile of known receptor affinity similar to that of clozapine. This pilot study examined the efficacy of olanzapine for treatment-refractory childhood-onset schizophrenia in eight patients who had received 8-week open-label trials. For comparison, data are included from 15 patients who had received 6-week open-label clozapine trials using identical rating instruments (largely by the same raters) in the same treatment setting. Twenty-three children and adolescents with an onset of DSM-III-R schizophrenia by age 12 for whom at least two different typical neuroleptics had been ineffective participated in the two separate studies. Some of the patients were intolerant of clozapine, although it had been effective (n = 4). Patients receiving olanzapine were evaluated over 8 weeks with the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Positive Symptoms, the Scale for the Assessment of Negative Symptoms, and the Clinical Global Impressions Scale for Improvement. For the eight patients who received olanzapine trials, at week 8 there was a 17% improvement in the BPRS total score, a 27% improvement in the Scale for the...Continue Reading

References

Jan 1, 1992·Schizophrenia Bulletin·H Y Meltzer
Jan 1, 1970·Acta Psychiatrica Scandinavica. Supplementum·G M Simpson, J W Angus
Nov 1, 1983·Archives of General Psychiatry·D ShafferS Aluwahlia
Jun 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·K E TowbinR G Pugliese
Oct 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·J Alaghband-RadJ L Rapoport
Jan 1, 1994·Schizophrenia Bulletin·C T GordonK E Albus
Dec 1, 1994·The American Journal of Psychiatry·J A LiebermanJ M Kane
Jun 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·K McKennaJ L Rapoport
Jun 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·L K JacobsenJ L Woolston
Jun 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·J A FrazierJ L Rapoport
Jan 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·T MozesA Weizman
Feb 15, 1996·Biological Psychiatry·S SzymanskiM Kronig
Jul 1, 1996·Archives of General Psychiatry·J A FrazierJ L Rapoport
Jan 1, 1996·Schizophrenia Bulletin·T H McGlashan, J O Johannessen
Dec 1, 1996·Archives of General Psychiatry·S KumraJ L Rapoport
Oct 24, 1997·Archives of General Psychiatry·J L RapoportS Hamburger
Oct 24, 1997·Archives of General Psychiatry·T P ZahnJ L Rapoport
Jan 1, 1997·Harvard Review of Psychiatry·R L Borison
Apr 16, 1998·Journal of Child Psychology and Psychiatry, and Allied Disciplines·L K Jacobsen, J L Rapoport
Sep 1, 1963·Archives of General Psychiatry·W E BUNNEY, D A HAMBURG

❮ Previous
Next ❯

Citations

Apr 30, 1999·Journal of Intellectual Disability Research : JIDR·G MasiP Poli
Feb 14, 2006·European Child & Adolescent Psychiatry·Jorge L Armenteros, Mark Davies
Sep 10, 2008·Journal of Neural Transmission·Christian FleischhakerAndreas Warnke
Feb 25, 1998·Journal of the American Academy of Child and Adolescent Psychiatry·S KumraJ L Rapoport
Aug 22, 2002·Journal of Child and Adolescent Psychopharmacology·Cara L AlfaroJudith L Rapoport
Nov 13, 2002·Journal of Child and Adolescent Psychopharmacology·Nick C PatelM Lynn Crismon
Jun 14, 2003·Journal of Child and Adolescent Psychopharmacology·Brian McConvilleKerri Browne
Dec 4, 2003·Journal of Child and Adolescent Psychopharmacology·Tamar MozesRoberto Mester
May 15, 2004·Journal of Child and Adolescent Psychopharmacology·Deanna L KellyRobert R Conley
Jan 15, 2005·Journal of Child and Adolescent Psychopharmacology·Jennifer Cheng-ShannonJames T McCracken
Jun 14, 2006·Journal of Child and Adolescent Psychopharmacology·Christian FleischhakerAndreas Warnke
Sep 9, 2006·Journal of Child and Adolescent Psychopharmacology·Tamar MozesAbraham Weizman
Sep 2, 2008·Journal of Child and Adolescent Psychopharmacology·Jonathan B JensenS Charles Schulz
Jan 1, 2007·International Journal of Psychiatry in Clinical Practice·Michal Hrdlicka, Iva Dudova
Mar 16, 2001·Expert Opinion on Pharmacotherapy·R L FindlingB L Gracious
Jul 24, 2013·Expert Opinion on Drug Safety·Charles Schulz, Robert J Haight
Jun 7, 2005·Expert Opinion on Emerging Drugs·Yavuz S Silay, Joseph Jankovic
Sep 24, 1999·Current Medical Research and Opinion·B Green
Feb 26, 2004·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Joan Rosenbaum AsarnowEmily P McGrath
Aug 2, 2008·Expert Opinion on Pharmacotherapy·Vishal MadaanDaniel R Wilson
Jan 29, 2008·Expert Opinion on Pharmacotherapy·Jeffrey R Strawn, Melissa P Delbello
Oct 6, 2006·Expert Opinion on Pharmacotherapy·Suad Kapetanovic, George M Simpson
Apr 20, 2016·Journal of Child and Adolescent Psychopharmacology·Zainab Al-DhaherMaren Carbon
Dec 2, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Celso ArangoDolores Maria Moreno
May 5, 2000·The Cochrane Database of Systematic Reviews·A TuunainenS M Gilbody
Aug 30, 2001·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·L Baving, M H Schmidt
Nov 17, 2006·Journal of Neural Transmission·C FleischhakerA Warnke
Nov 24, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Paz TorenAbraham Weizman
Jan 5, 2002·Paediatric Drugs·K A StiglerC J McDougle
Jan 5, 2001·European Child & Adolescent Psychiatry·H RemschmidtE Schulz
Sep 9, 2008·European Psychiatry : the Journal of the Association of European Psychiatrists·Jaana JuutinenUNKNOWN Study-70 Research Group
Oct 26, 2000·The Journal of Nervous and Mental Disease·A S Kablinger, A M Freeman
Apr 19, 2000·Journal of Clinical Psychopharmacology·D R GrotheD L Kurtz
Aug 1, 2002·European Psychiatry : the Journal of the Association of European Psychiatrists·W W Fleischhacker
Jul 19, 2020·Clinical Psychology & Psychotherapy·Kimberley GinSuzanne Jolley
Apr 4, 2000·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·H RemschmidtE Schulz
Sep 21, 2016·The Cochrane Database of Systematic Reviews·Simon GilbodyArja Tuunainen
Jan 5, 2002·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·G WalterV Storm
Jun 6, 2018·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Jennifer PillayNormand Carrey
Dec 3, 2005·Child and Adolescent Psychiatric Clinics of North America·Harvey N KranzlerSanjiv Kumra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

© 2022 Meta ULC. All rights reserved