Childhood onset schizophrenia: familial neurocognitive measures

Schizophrenia Research
Peter GochmanJ L Rapoport

Abstract

Early onset disorders may have more salient familial/genetic etiology. Neurocognitive deficits which are seen in families of adult onset schizophrenic patients were examined in healthy family members of patients with childhood-onset schizophrenia (COS). Trail Making Tests (TMT) A and B, Wechsler Intelligence Scale-Revised Digit Span and Vocabulary subtests were administered to 67 parents and 24 siblings of patients with childhood-onset schizophrenia and 114 healthy community controls (CC) comparable in sex, age, and educational level. COS siblings performed significantly more poorly than did controls on Trails Making Test B with a trend for poorer performance evident on Trails Making Test A. COS parents performed more poorly than controls only on Trails Making Test A. Healthy first-degree relatives of COS probands have subtle deficits in tests involving oculomotor/psychomotor speed, working memory and executive function. This provides further support for continuity between COS and later onset schizophrenia and for a familial/genetic factor associated with the illness.

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Citations

Jul 25, 2006·Archives of Disease in Childhood·P A McArdle
May 2, 2008·Schizophrenia Bulletin·S Kristian HillJohn A Sweeney
Feb 9, 2005·Molecular Psychiatry·J L RapoportM R C Psych
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Oct 1, 2008·Journal of the American Academy of Child and Adolescent Psychiatry·Nitin Gogtay, Judith L Rapoport
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Mar 3, 2018·Journal of the American Academy of Child and Adolescent Psychiatry·Frances F LoebSiyuan Liu

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