Childhood onset temporal lobe epilepsy: Beyond hippocampal sclerosis

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
Angelika MühlebnerMartha Feucht

Abstract

Hippocampal Sclerosis (HS) is widely recognized as a significant underlying cause of drug-resistant temporal lobe epilepsy (TLE) in adults. In contrast, HS is a rare finding in pediatric surgical series, and a higher incidence of HS associated with cortical dysplasia (i.e. FCD type IIIa according to the new ILAE classification) than in adult series has been reported. Data about the electro-clinical characteristics of this subgroup are scarce. We studied 15 children and adolescents with drug-resistant TLE and HS who had anterior temporal lobe resection at our center with regard to electroclinical characteristics, MRI features and histopathology. Children in whom histopathology was consistent with Focal Cortical Dysplasia (FCD) type IIIa (n = 7) were compared with those who had HS only (n = 8). Clinical characteristics associated with this highly selective subset of patients with FCD type IIIa were: the presence of febrile seizures during infancy, a shorter duration of active epilepsy and a lower age at epilepsy surgery. In addition, there were non-significant trends towards more extended abnormalities on both EEG and neuroimaging. We were, however, not able to find group differences with respect to neuropathologic subtyping of t...Continue Reading

References

Mar 30, 2004·Annals of Neurology·Sofia H ErikssonSanjay M Sisodiya
Sep 18, 2007·Epilepsia·Bruno MatonMichael Duchowny
Nov 29, 2007·Epilepsia·A Simon HarveyUNKNOWN ILAE Pediatric Epilepsy Surgery Survey Taskforce
Jul 17, 2009·Journal of Neuropathology and Experimental Neurology·Maria ThomSanjay M Sisodiya
Sep 4, 2012·Handbook of Clinical Neurology·Maria Thom, Edward H Bertram
Sep 14, 2012·Epilepsia·Kristina Malmgren, Maria Thom
Oct 3, 2012·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·William O Tatum
Oct 3, 2012·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Jeffrey D Kennedy, Stephan U Schuele
Dec 17, 2014·Epilepsia·Susanne FauserAndreas Schulze-Bonhage
Jul 8, 2015·Epilepsia·Susanne Fauser, Andreas Schulze-Bonhage

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Citations

Jul 31, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Julia HuemerMartha Feucht
Apr 18, 2018·Developmental Neurobiology·Michal KielbinskiKrzysztof Janeczko
Aug 9, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Alican Tahta, Mehmet Turgut

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