Childhood Origins of Adult Lung Disease as Opportunities for Prevention.

The Journal of Allergy and Clinical Immunology. in Practice
Torie GrantMeredith C McCormack

Abstract

Prenatal and childhood exposures have been shown to impact lung development, lung function trajectory, and incidence and prevalence of respiratory disease. Early life may serve as a window of susceptibility to such exposures, with the potential to influence lifelong respiratory health. Risk factors encountered in early life with potentially durable impact on lung health include prematurity, respiratory viral illness, allergen sensitization and exposure, tobacco use and exposure, indoor and outdoor pollution, diet, and obesity. These exposures vary in the extent to which they are modifiable, and interventions aimed at reducing harmful exposures range from individual-level behavior modification to policy initiatives implemented to promote population health. For many exposures, including tobacco-related exposures, multilevel interventions are needed. Future research is needed to provide insight as to early-life interventions to promote optimal lung growth and prevent development of chronic respiratory disease. Clinicians should play an active role, assisting individual patients in avoiding known detrimental exposures including maternal smoking during pregnancy and initiation of active smoking. Clinicians can be empowered by eviden...Continue Reading

Citations

Oct 30, 2020·Journal of Clinical Medicine·Joon Young Choi, Chin Kook Rhee
May 15, 2021·Frontiers in Physiology·Marta SchiliroChristina M Pabelick
May 18, 2021·JAMA Pediatrics·Christine Cole JohnsonUNKNOWN Environmental Influences on Child Health Outcomes (ECHO) collaborators
Jul 13, 2021·Environmental Research·Hongyao YuGuang-Hui Dong
Jun 23, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Julie D FlomKecia Carroll
Aug 28, 2021·Journal of Personalized Medicine·Serafeim-Chrysovalantis KotoulasAthanasia Pataka
Oct 22, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Torie GrantElizabeth C Matsui

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