Childhood pregnancy (10-14 years old) and risk of stillbirth in singletons and twins

The Journal of Pediatrics
Hamisu M SalihuGreg R Alexander

Abstract

To clarify the association between childhood pregnancy and risk of stillbirth. We analyzed singleton and twin pregnancies that occurred in children (10-14 years old) in the United States from 1989 to 2000. We estimated the absolute and relative risks of stillbirth by using 15- to19-year-old and 20- to 24-year-old mothers as comparison groups. The analysis involved 17.8 million singletons and 337,904 individual twins. The rate of stillbirth was highest in pediatric mothers for both singletons (12.8/1000) and twins (56/1000) compared with adolescent (6.8/1000 in singletons and 29/1000 in twins) and mature (5.5/1000 in singletons and 20/1000 in twins) mothers. After adjusting for confounding characteristics, pediatric mothers continued to exhibit significantly elevated risk for stillbirth in both singletons (odds ratio, 1.57; 95%CI, 1.49-1.66) and twins (odds ratio, 1.97; 95%CI, 1.42-2.73). Preterm birth rather than small size for gestational age was revealed by means of sequential modeling to account for the excess risk of stillbirth observed in pediatric gravidas. Pregnancy in childhood is a risk factor for stillbirth; shortened gestation rather than reduction in fetal growth is the mediating pathway.

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Citations

Jan 25, 2008·Archives of Gynecology and Obstetrics·Roneé E WilsonHamisu M Salihu
Oct 17, 2012·American Journal of Epidemiology·Emily W HarvilleYiqiong Xie
Aug 1, 2008·Public Health Nursing·Keila R O GomesLaís N B Moura
Jun 19, 2013·Maternal and Child Health Journal·Aubrey Spriggs MadkourYiqiong Xie
Dec 3, 2014·Journal de gynécologie, obstétrique et biologie de la reproduction·T QuibelP Rozenberg
Mar 15, 2011·Journal of Pediatric and Adolescent Gynecology·Hamisu M SalihuEstrellita Berry
Feb 15, 2011·Journal of Pediatric and Adolescent Gynecology·Sharon B Stechna
Feb 13, 2010·Journal of Pediatric and Adolescent Gynecology·Muktar H AliyuHeather B Clayton
Jul 26, 2008·Seminars in Perinatology·Hamisu M Salihu
Dec 2, 2006·The Journal of Pediatrics·Henrietta S BadaWendy F Hansen
Aug 4, 2015·Journal of Pediatric and Adolescent Gynecology·Yiqiong XieEmily Wheeler Harville
Jul 7, 2012·Paediatric and Perinatal Epidemiology·Cassandra M GibbsCarol J Hogue
Nov 19, 2014·Paediatric and Perinatal Epidemiology·María Clara Restrepo-MéndezCesar G Victora
Nov 5, 2014·Maternal and Child Health Journal·Patricia A Cavazos-RehgLaura Jean Bierut
Jan 24, 2015·Archives of Disease in Childhood·Joshua P VogelLale Say
Feb 10, 2012·Epidemiology·Nigel Paneth
Jun 18, 2021·European Journal of Pediatrics·Sahra IbrahimiHamisu M Salihu

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