Childhood retinol-binding protein 4 (RBP4) levels predicting the 10-year risk of insulin resistance and metabolic syndrome: the BCAMS study

Cardiovascular Diabetology
Ge LiSteven M Willi

Abstract

Elevated retinol-binding protein 4 (RBP4) levels may contribute to the development of metabolic abnormalities, but prospective studies evaluating the association between childhood RBP4 levels and metabolic syndrome (MS) in adulthood are lacking. We investigated whether RBP4 levels during childhood predict cardiometabolic risk at 10-year follow-up. The relationships between RBP4 levels, the established adipokines (leptin and adiponectin) and the components of MS were examined in 3445 school-aged children recruited in 2004 for the Beijing Child and Adolescent Metabolic Syndrome study. In 2015, 352 of these individuals completed an in-depth follow-up examination. Participants with higher childhood RBP4 levels had adverse cardiometabolic profiles at follow-up. Those with incident or persistent MS had higher baseline RBP4 levels than those who never exhibited the elements of MS. Moreover, baseline RBP4 predicted hyperglycemia (OR per SD increase = 1.48, P = 0.009), elevated triglyceride (OR = 1.54, P < 0.001), elevated blood pressures (OR = 1.46, P = 0.015), MS (OR = 1.68, P = 0.002) and insulin resistance (OR = 1.44, P = 0.015) in the 10-year follow-up phase, independent of baseline BMI. Significant improvements were seen for the n...Continue Reading

References

Jun 16, 2006·The New England Journal of Medicine·Timothy E GrahamBarbara B Kahn
Mar 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Prabhakaran BalagopalDonald George
Jun 7, 2007·The Journal of Clinical Endocrinology and Metabolism·Weiping JiaKunsan Xiang
Aug 30, 2007·The Journal of Clinical Endocrinology and Metabolism·Miriam PromintzerChristian Anderwald
Aug 30, 2007·The Journal of Clinical Endocrinology and Metabolism·Isabelle AeberliMichael B Zimmermann
Sep 20, 2007·The Journal of Clinical Endocrinology and Metabolism·Qibin QiXu Lin
Apr 10, 2008·The Journal of Clinical Endocrinology and Metabolism·Thomas ReinehrChristian L Roth
May 20, 2008·Clinical Chemistry·Christina Kanaka-GantenbeinIoannis Papassotiriou
Mar 18, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M LiK Cianflone
Oct 2, 2009·Journal of Endocrinological Investigation·N SantoroE Miraglia del Giudice
Oct 20, 2009·The Journal of Clinical Endocrinology and Metabolism·Jennifer K GustafsonJack A Yanovski
Nov 3, 2009·International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity·Ameet M TailorDora Romaguera
Oct 19, 2010·International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity·D FriebeA Körner
Nov 6, 2010·Journal of Obesity·Jie MiKatherine Cianflone
Jan 4, 2013·Diabetes Care·UNKNOWN American Diabetes Association
May 30, 2015·Trends in Pharmacological Sciences·Mathias Fasshauer, Matthias Blüher
May 5, 2016·Cardiovascular Diabetology·François R JornayvazPedro Marques-Vidal

❮ Previous
Next ❯

Citations

Apr 9, 2020·Frontiers in Endocrinology·Linjie WangFengying Gong
Jul 29, 2020·International Journal of Molecular Sciences·Anna Maria RychterIwona Krela-Kaźmierczak
Oct 13, 2020·Journal of Paediatrics and Child Health·Katarzyna ZdanowiczDariusz Marek Lebensztejn
Nov 24, 2020·Cardiovascular Diabetology·María J GuembeUNKNOWN RIVANA Study Investigators
Apr 6, 2021·Frontiers in Cell and Developmental Biology·Li-Min LeiLing-Qing Yuan
May 7, 2021·Molecular and Cellular Endocrinology·Pamela A Nono Nankam, Matthias Blüher
Feb 27, 2021·Journal of Pediatric Gastroenterology and Nutrition·Ana Pilar Nso-RocaFrancisco Sánchez Ferrer
Nov 14, 2020·Current Pharmaceutical Design·Eleni P KotanidouAssimina Galli-Tsinopoulou
Oct 31, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Ge LiShan Gao

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Clinical Trials Mentioned

NCT03421444

Software Mentioned

Medcalc
TOSOH
SPSS
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.