PMID: 8470759May 1, 1993Paper

Childhood rhabdomyosarcoma with anaplastic (pleomorphic) features. A report of the Intergroup Rhabdomyosarcoma Study

The American Journal of Surgical Pathology
R KodetH M Maurer

Abstract

The pleomorphic subtype of rhabdomyosarcoma (RMS) is now rarely diagnosed in both children and adults. Most cases previously called pleomorphic RMS are probably diagnosed as something else, most often embryonal RMS in children and malignant fibrous histiocytoma in adults. To analyze the concept of pleomorphic RMS in children, we reviewed the tumors of patients entered on the Inter-group Rhabdomyosarcoma Study (IRS I, II, and III). The presence of cells with lobated, hyperchromatic nuclei at least three times larger than the common tumor cell population (anaplastic cells) was selected as the main criterion. Of about 3,000 cases, 110 showed these types of cells, had sufficient histologic material, and had available follow-up data. These tumors were divided into two subgroups: Subgroup I tumors contained only scattered anaplastic cells, and tumors with foci or large sheets of anaplastic cells were classified as subgroup II. Besides the anaplastic-pleomorphic areas, most of these tumors had distinctive features of embryonal RMS (105 cases) and rarely had characteristics of alveolar RMS (five cases). The age distribution of these patients did not differ significantly from those whose tumors did not show the anaplastic features, the ...Continue Reading

Citations

Dec 16, 1998·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·S J QualmanW M Crist
Jan 26, 1999·Medical and Pediatric Oncology·J BaraniyaA Borges
Nov 26, 1999·Medical and Pediatric Oncology·M T Di TullioC Morgera
May 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·D M Parham
Apr 12, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jun NishioJulia A Bridge
Mar 24, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Kathleen NicolUNKNOWN Children's Oncology Group, Soft Tissue Sarcoma Committee
Dec 20, 2005·Histopathology·A P Dei Tos
Jun 6, 2008·Journal of Pediatric Hematology/oncology·Henry L ChangPeter T Masiakos
Dec 7, 2005·Advances in Anatomic Pathology·Jesse K McKenney
Jul 11, 2006·Journal of Pediatric Hematology/oncology·Alan DavidsonColin Sinclair-Smith
Jan 3, 2014·Cancer·Simone HettmerDavid Malkin
May 11, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·David M ParhamCheryl M Coffin
Apr 7, 1999·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·W A NewtonH M Maurer
Mar 8, 2008·Pediatric Radiology·Rick R Van RijnJohannes H M Merks
May 1, 2008·Ultrastructural Pathology·Julia A Bridge
Apr 30, 2015·Journal of the Egyptian National Cancer Institute·Iman SidhomMohamed Sabry
Aug 16, 2012·The Journal of Laryngology and Otology·R ExleyM P Rothera
Nov 7, 2019·Virchows Archiv : an International Journal of Pathology·Julia Leiner, François Le Loarer
Jul 14, 2020·Pediatric Blood & Cancer·Morgane PondromLaurence Brugières
Aug 28, 2003·Archives of Gynecology and Obstetrics·R A CarusoM Starrantino
May 29, 2007·The American Journal of Surgical Pathology·David M ParhamUNKNOWN Soft Tissue Sarcoma Committee of the Children's Oncology Group
Oct 12, 2012·Paediatric Drugs·Yasmin GosiengfiaoDavid Walterhouse
Feb 23, 2010·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Oluwole FadareVinita Parkash
Dec 21, 2007·Virchows Archiv : an International Journal of Pathology·Tadaki MatsumuraTadashi Hasegawa
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John C BrenemanWilliam M Crist
May 22, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer A BennettEsther Oliva
Nov 9, 2006·Archives of Pathology & Laboratory Medicine·David M Parham, Dale A Ellison
Apr 30, 2005·Archives of Pathology & Laboratory Medicine·Gladell P PanerRasheed Hammadeh
Oct 7, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Keisuke KatoMasahiro Tsuchida
Dec 11, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Archana ShenoyErin R Rudzinski

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