Childhood serum cholesterol ester fatty acids are associated with blood pressure 27 y later in the Cardiovascular Risk in Young Finns Study

The American Journal of Clinical Nutrition
Jari E KaikkonenOlli T Raitakari

Abstract

In adults, dietary fatty acids (FAs) modify blood pressure (BP), but it is not known whether childhood FA quality is associated with adulthood BP. The purpose of the study was to investigate links between childhood serum cholesterol ester fatty acid (CEFA) proportions and adulthood systolic blood pressure (SBP) and diastolic blood pressure (DBP). We examined a cohort of 803 boys and girls (aged 3-18 y at baseline in 1980 and followed for 27 y) by using regression models adjusted for the known risk factors of BP. CEFAs were analyzed as markers of dietary FA intake. In men, serum SFA (B = 2.97, P < 0.001 for SBP; B = 1.48, P = 0.015 for DBP), MUFA (B = 0.61, P = 0.001 for SBP; B = 0.27, P = 0.078 for DBP), and omega-3 (n-3) PUFA (B = 5.50, P < 0.001 for SBP; B = 2.47, P = 0.015 for DBP) proportions, which were derived mainly from animal fats in this population, were positively associated with BP, whereas the omega-6 (n-6) PUFA proportion, which was derived mainly from vegetable oils and margarines, was negatively associated with BP (B = -0.56, P < 0.001 for SBP; B = -0.27, P < 0.018 for DBP). Serum cholesterol ester SFA and PUFA associations were supported by dietary intake data. In women, the associations between CEFA proportion...Continue Reading

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Citations

Oct 17, 2012·Current Opinion in Lipidology·Markus JuonalaOlli T Raitakari
Jan 10, 2013·Current Opinion in Lipidology·Dawn C Schwenke
Dec 25, 2012·Italian Journal of Pediatrics·Ornella GuardamagnaLorenzo Lughetti
Aug 6, 2014·Current Atherosclerosis Reports·Jari E KaikkonenOlli T Raitakari
Dec 10, 2015·Immunology and Cell Biology·Agnieszka Mika, Monika Fleshner
Apr 30, 2015·The Journal of Nutrition, Health & Aging·A N NyantikaJ K Virtanen
Sep 16, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M WoltersW Ahrens
Nov 15, 2013·International Journal of Food Sciences and Nutrition·Katri NiinivirtaKirsi Laitinen
Jun 18, 2014·Arquivos brasileiros de endocrinologia e metabologia·Milena Miranda de Moraes, Gloria Valeria da Veiga

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