Childhood trauma and clinical high risk for psychosis

Schizophrenia Research
Rachel L LoewySophia Vinogradov

Abstract

As a risk factor for psychosis, childhood trauma rates are elevated in the clinical-high-risk (CHR) syndrome compared to the general population. However, it is unknown whether trauma is typically experienced in childhood or adolescence/young adulthood, whether it occurred prior to CHR syndrome onset, and how severe trauma relates to presenting symptoms. In this study, we examined the relationship of trauma history to symptoms and functioning in individuals diagnosed with the CHR syndrome on the Structured Interview for Psychosis-Risk Syndromes (N = 103). Trauma, defined as meeting the DSM-IV A1 criterion of actual or threatened death or injury, was assessed by semi-structured interview. A large proportion of CHR participants (61%) reported trauma exposure, including interpersonal trauma, trauma prior to CHR onset, and childhood trauma prior to age 12. Those with a trauma history (versus those without trauma) were rated as having more severe perceptual disturbances, general/affective symptoms and more impairment on the Global Assessment of Functioning Scale. The number of traumatic events correlated with more severe ratings in those three domains. Additionally, the number of interpersonal traumas was correlated with ratings of s...Continue Reading

Citations

May 1, 2019·Current Psychiatry Reports·Jean AddingtonMohammed Shakeel Kalathil
Dec 14, 2019·The Journal of Nervous and Mental Disease·Jacqueline StowkowyJean Addington
Sep 29, 2019·Journal of Clinical Medicine·Arielle Ered, Lauren M Ellman
Nov 12, 2019·Child and Adolescent Psychiatric Clinics of North America·Kate J StantonYael Dvir
Nov 3, 2020·Frontiers in Cell and Developmental Biology·Jinbao WeiJinghong Chen
Mar 22, 2021·Journal of Psychiatric Research·Ahmad MayeliFabio Ferrarelli
Dec 4, 2021·European Archives of Psychiatry and Clinical Neuroscience·Renata Pionke-UbychŁukasz Gawęda

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