Mar 27, 2015

Childhood trauma and cortisol awakening response in symptomatic patients with anorexia nervosa and bulimia nervosa

The International Journal of Eating Disorders
Alessio Maria MonteleoneMario Maj


Exposure to trauma during childhood is a risk factor for eating disorders (EDs) in adulthood. The biological mechanisms underlying such increased risk seem to involve the endogenous stress response system (i.e., the hypothalamic-pituitary-adrenal [HPA] axis), which undergoes trauma-induced functional changes that may persist later in life. In the present study, we examined the effects of childhood trauma experiences on HPA-axis activity, comparing saliva cortisol awakening response (CAR) in adult patients with anorexia nervosa (AN) or bulimia nervosa (BN) with CAR in adult healthy controls. Twenty-three patients with symptomatic AN, 21 patients with symptomatic BN, and 29 healthy women collected saliva samples at awakening and again after 15, 30, and 60 min. Participants also completed the Childhood Trauma Questionnaire and eating-related psychopathological rating scales. According to the Childhood Trauma Questionnaire, 13 individuals with AN and 12 individuals with BN, but none of the healthy women, reported childhood maltreatment. Compared with the control group, the non-maltreated AN patient group exhibited an enhanced CAR, whereas the group of non-maltreated BN patients showed a normal CAR. Moreover, both AN and BN patient ...Continue Reading

  • References35
  • Citations17


  • References35
  • Citations17


Mentioned in this Paper

Biological Adaptation to Stress
Pituitary Diseases
Saliva - SpecimenType
Hypothalamus-pituitary Axis
Trauma and Stressor Related Disorders

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