Childhood vitiligo: response to methylprednisolone oral minipulse therapy and topical fluticasone combination.

Indian Journal of Dermatology
Imran MajidMuzammil Chisti

Abstract

Childhood vitiligo is always a challenge to treat, especially when the disease is progressing rapidly in such a patient. Oral minipulse with betamethasone has been tried in childhood vitiligo and also in some other immune mediated skin disorders with good results. The aim of the present study was to see the overall efficacy of methylprednisolone oral minipulse therapy in combination with topical fluticasone in progressive childhood vitiligo. The combination was tried to achieve a significant amount of repigmentation of vitiligo lesions already present at the initial visit. Four hundred children with progressive vitiligo were enrolled for this study and were prescribed oral methylprednisolone on two consecutive days every week in a minipulse form for a period of six months. In addition, the patients were instructed to apply fluticasone ointment topically once a day on their vitiligo lesions. The patients were assessed for the remission achieved as well as the extent of repigmentation of their already existent lesions. More than 90% of patients went into complete remission after the start of the therapy. Moreover, about 65% (two-thirds) of patients achieved good to excellent repigmentation of lesions at the end of six months of t...Continue Reading

References

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Citations

Nov 24, 2016·Pediatric Dermatology·Andreia Freire de MenezesAdriano Antunes de Souza Araújo
Jul 3, 2013·Journal of Cutaneous Medicine and Surgery·Amrinder J KanwarDavinder Parsad
Apr 13, 2019·Dermatologic Therapy·Imran MajidSameena Batool
Sep 11, 2020·Photodermatology, Photoimmunology & Photomedicine·Jung Min BaeChul Jong Park

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