Children of a lesser god: exclusion of chronic kidney disease patients from clinical trials

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Carmine ZoccaliChristoph Wanner

Abstract

The exclusion of chronic kidney disease (CKD) patients from clinical trials-particularly cardiovascular trials-remains a long-standing, unsolved problem, which prevents the optimization of clinical care in these patients. The situation recalls the insufficient recruitment of women in cardiovascular trials until the 1980s, a problem that was only resolved following regulatory interventions. Regulatory agencies are in a unique position to promote recruitment of CKD patients in clinical trials. The main stakeholders, namely patients' associations and scientific societies, should make major lobbying efforts to persuade these agencies that the issue is an absolute public health priority.

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Citations

Feb 1, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jose Luis GórrizMaria Jose Soler
Feb 6, 2020·The Journal of Clinical Investigation·Vivek A Rudrapatna, Atul J Butte
Dec 19, 2019·Frontiers in Cell and Developmental Biology·Michele ProvenzanoDavide Bolignano
Nov 6, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marie Hilderman, Annette Bruchfeld
Nov 20, 2020·Seminars in Dialysis·Katie E Cardone, Wendy M Parker
Dec 20, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·UNKNOWN ERA-EDTA Council, UNKNOWN ERACODA Working Group
Apr 25, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Julie H IshidaCharles A Herzog
Jul 3, 2021·Journal of Clinical Medicine·Clara García-CarroMaría José Soler
Sep 26, 2021·Diseases of the Colon and Rectum·Eleanor D Lederer, Michael E Brier

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