Children with Chronic Disease Bear the Highest Burden of Pediatric Sepsis

The Journal of Pediatrics
Andrew J ProutSachin Yende

Abstract

To describe the contemporary epidemiology of pediatric sepsis in children with chronic disease, and the contribution of chronic diseases to mortality. We examined the incidence and hospital mortality of pediatric sepsis in a nationally representative sample and described the contribution of chronic diseases to hospital mortality. We analyzed the 2013 Nationwide Readmissions Database using a retrospective cohort design. We included non-neonatal patients <19 years of age hospitalized with sepsis. We examined patient characteristics, the distribution of chronic disease, and the estimated national incidence, and described hospital mortality. We used mixed effects logistic regression to explore the association between chronic diseases and hospital mortality. A total of 16 387 admissions, representing 14 243 unique patients, were for sepsis. The national incidence was 0.72 cases per 1000 per year (54 060 cases annually). Most (68.6%) had a chronic disease. The in-hospital mortality was 3.7% overall-0.7% for previously healthy patients and 5.1% for patients with chronic disease. In multivariable analysis, oncologic, hematologic, metabolic, neurologic, cardiac and renal disease, and solid organ transplantation were associated with incr...Continue Reading

Citations

Feb 8, 2020·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Scott L WeissPierre Tissieres
Jun 23, 2020·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Ayse Filiz Yetimakman, Eylem Kıral
Nov 5, 2020·Journal of the American College of Emergency Physicians Open·Andrea T CruzLuregn J Schlapbach
Feb 14, 2021·The American Journal of Emergency Medicine·Emily HegamyerAndrew D Depiero
Jun 24, 2021·Medicine·Thomas SchmochThorsten Brenner
Oct 7, 2021·Critical Care Medicine·Kusum MenonUNKNOWN Pediatric Sepsis Definition Taskforce of the Society of Critical Care Medicine

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