PMID: 16622996Apr 21, 2006Paper

Children with clinical central diabetes insipidus at King Chulalongkorn Memorial Hospital

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Somlak KittayalaksakunSumarlee Srivuthana

Abstract

To determine the etiologies and associated endocrine disorders in children with central diabetes insipidus (DI). The authors retrospectively reviewed the medical records of children with central DI, who were admitted at department of Pediatrics, King Chulalongkorn Memorial Hospital, between 2000 and 2004. Aims of this study were to identify the etiology of central DI in children and also described the anterior pituitary hormone insufficiencies which may occur. Of the total 51 patients, 27 patients were males and 24 were females. Intracranial tumors produced DI in 36 children (70.6%), but 17 of these 36 children (47.22%) had DI before surgical removal of the tumors. Fifteen patients (29.4%) had DI from non-tumor causes, which include idiopathic in 2 patients (13.5%), terminal events in 4 patients (26.8%), central nervous system (CNS) infection in 5 patients (33.3%), CNS anomalies in 2 patients (13.5%), Kabuki syndrome in 1 patient (6.6%), head injury in 1 patient (6.6%). Anterior pituitary function was evaluated in all tumor group and 8 patients of non-tumor group. In intracranial tumor group, growth hormone deficiency (GHD) was documented in 14 from 22 patients (63.6%), secondary adrenal insufficiency in 13 from 20 patients (65...Continue Reading

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