Children with type 1 diabetes who experienced a honeymoon phase had significantly lower LDL cholesterol 5 years after diagnosis

PloS One
Benjamin Udoka NwosuBruce A Barton

Abstract

Landmark studies showed that partial clinical remission in new-onset type 1 diabetes is associated with reduced prevalence of long-term complications, but early clinical indicators of this favorable outcome are poorly characterized. To determine if there were any differences in lipid parameters, especially LDL-cholesterol, between remitters and non-remitters 4 to 5 years after the diagnosis of type 1 diabetes after controlling for hemoglobin A1c, body mass index, and pubertal status. A longitudinal retrospective cohort study of 123 subjects of mean age 11.9 ± 2.9 years, [male 11.7 ± 2.9 years, (n = 55); female 12.0 ± 2.9 years, (n = 68), p = 0.60] with type 1 diabetes of 4-5 years duration. Anthropometric and biochemical data were collected at the 4th or 5th year after diagnosis in line with the American Diabetes Association recommendation to initiate screening for complications in children either at the beginning of puberty or 4-5 years after diagnosis. Puberty was defined by Tanner stages II-V. Partial clinical remission was defined by the gold-standard insulin-dose adjusted hemoglobin A1c (IDAA1c) of ≤9. There were 44 (35.8%) remitters (age 13.0 ± 2.5y; male 52.3%). Both the total cholesterol and LDL-cholesterol were signifi...Continue Reading

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Citations

Apr 2, 2019·Journal of the Endocrine Society·Benjamin Udoka NwosuBruce A Barton
Jul 8, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Benjamin Udoka NwosuBruce A Barton
Aug 9, 2020·Journal of the Science of Food and Agriculture·Maísa Lamounier MagalhãesMaria das Graças Cardoso
Jul 9, 2020·International Journal of Environmental Research and Public Health·Stefano PassanisiFortunato Lombardo
Apr 17, 2021·Journal of the Endocrine Society·Benjamin Udoka NwosuAustin F Lee
Dec 14, 2021·Frontiers in Endocrinology·Benjamin Udoka NwosuAustin F Lee

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Methods Mentioned

BETA
PCR

Software Mentioned

R
R Foundation for Statistical Computing

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