Children With Unilateral Cerebral Palsy Utilize More Cortical Resources for Similar Motor Output During Treadmill Gait

Frontiers in Human Neuroscience
Matthew R ShortThomas C Bulea

Abstract

Children with unilateral cerebral palsy (CP) walk independently although with an asymmetrical, more poorly coordinated pattern compared to their peers. While gait biomechanics in unilateral CP and their alteration from those without CP have been well documented, cortical mechanisms underlying gait remain inadequately understood. To the best of our knowledge, this is the first study utilizing electroencephalography (EEG) during treadmill gait in older children with and without CP. Lower limb surface electromyographic (EMG) data were collected and muscle synergy analyses performed to quantify motor output. Our primary goal was to evaluate the relationships between cortical and muscle activation within and across groups and hemispheres to provide novel insights into neural control of gait and how it may be disrupted by an early unilateral brain injury. Participants included 9 children with unilateral CP, mean age 16.0 ± 2.7 years, and 12 with typical development (TD), mean age 14.8 ± 3.0 years. EEG data were collected during a standing baseline and treadmill walking at self-selected speed. EMG of 16 lower limb muscles were also collected bilaterally and synchronized with EEG. No significant group differences were found in synergy ...Continue Reading

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Citations

Sep 26, 2020·Frontiers in Bioengineering and Biotechnology·Germana CappelliniYury Ivanenko
Jul 16, 2020·Journal of Neurophysiology·G CappelliniY Ivanenko
Nov 12, 2020·Annals of Clinical and Translational Neurology·Max J KurzTony W Wilson
Dec 29, 2020·Frontiers in Neurology·Germana CappelliniYury Ivanenko
May 28, 2021·Frontiers in Human Neuroscience·Margit M BachNadia Dominici

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Methods Mentioned

BETA
infrared spectroscopy
PCA

Software Mentioned

RUNICA
EEGLAB
custom
ASR
DIPFIT
Matlab
Motion
Visual 3D

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