Chimeric antigen receptor-redirected T cells return to the bench

Seminars in Immunology
Claudia GeldresGianpietro Dotti

Abstract

While the clinical progress of chimeric antigen receptor T cell (CAR-T) immunotherapy has garnered attention to the field, our understanding of the biology of these chimeric molecules is still emerging. Our aim within this review is to bring to light the mechanistic understanding of these multi-modular receptors and how these individual components confer particular properties to CAR-Ts. In addition, we will discuss extrinsic factors that can be manipulated to influence CAR-T performance such as choice of cellular population, culturing conditions and additional modifications that enhance their activity particularly in solid tumors. Finally, we will also consider the emerging toxicity associated with CAR-Ts. By breaking apart the CAR and examining the role of each piece, we can build a better functioning cellular vehicle for optimized treatment of cancer patients.

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Citations

Jul 28, 2016·The Journal of Clinical Investigation·Xiaopei Huang, Yiping Yang
Oct 16, 2016·Biomolecules & Therapeutics·Young Uk KimYeonseok Chung
Nov 17, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marie-Louise SentmanCharles L Sentman
Oct 6, 2017·Expert Opinion on Biological Therapy·Elisa Landoni, Barbara Savoldo
Feb 7, 2020·Expert Opinion on Biological Therapy·Steven H ShenJohn H Sampson
Jan 6, 2017·Bioscience Reports·Huan-Huan ShaJi-Feng Feng
Apr 26, 2019·Therapeutic Advances in Hematology·Julio C ChavezMohamed A Kharfan-Dabaja
Jan 9, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuhui ChenBarbara Savoldo
Sep 27, 2020·Nature Reviews. Clinical Oncology·Lekha Mikkilineni, James N Kochenderfer
Apr 17, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raghuveer RanganathanGianpietro Dotti
Aug 16, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Leah AlabanzaJames N Kochenderfer

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